根据现代分子遗传学成果诊断和治疗卵巢癌

Q4 Medicine
E. Kagirova, R. Khusainova, I. Minniakhmetov
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引用次数: 0

摘要

该研究旨在系统整理和总结有关卵巢癌临床和遗传学、分子发病机制以及诊断和治疗新趋势研究的文献资料。使用 Web of science、scopus、medline、pubmed 和 elibrary 数据库进行文献检索。卵巢癌是一种异质性疾病,由不同类型的肿瘤组成,每种肿瘤在发病机制、特征基因的谱系和突变频率、对治疗的反应以及疾病的预后方面都存在差异。迄今为止,卵巢癌研究的优先领域是改进诊断方法、妇女检查算法、确定新的生物标志物、研究肿瘤微环境和腹水成分,以便在早期阶段发现癌症并进行适当治疗。基于肿瘤分子特征的靶向治疗的最新进展使个性化治疗和提高治疗效果成为可能。分子遗传学、细胞学、免疫学和生化研究方面的成就有助于开发诊断和治疗卵巢癌的新方法。随着新型卵巢癌诊断和治疗方法的出现,人们越来越清楚地认识到,肿瘤微环境会对化疗的成功与否产生重大影响。新的生物标志物有助于确定卵巢癌治疗的最佳候选者。需要进一步开展基础研究和应用研究,探索不同诊断和治疗药物在卵巢癌中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements
The purpose of the study was to systematize and summarize the literature data on the study of clinical and genetic aspects, molecular pathogenesis, as well as new trends in the diagnosis and treatment of ovarian cancer.Material and Methods. A literature search was conducted using Web of science, scopus, medline, pubmed, and elibrary databases.Results. Ovarian cancer is the leading cause of death in women diagnosed with gynecological cancer. ovarian cancer is a heterogeneous disease composed of different types of tumors, each of which has differences in pathogenesis, spectrum and mutation frequencies in characteristic genes, response to therapy and prognosis of the disease. more than 80 % of all malignant ovarian tumors are of epithelial origin (carcinomas) and about 26 % of all cases of ovarian cancer are caused by germline mutations found in the BRCA1/BRCA2 genes. to date, the priority areas in the study of ovarian cancer are the improvement of diagnostic methods, algorithm of examination of women, identification of new biomarkers, study of tumor microenvironment and composition of ascitic fluid to detect cancer at early stages and prescribe appropriate therapy. Recent advances in targeted therapy based on the molecular profile of the tumor have made it possible to personalize treatment and increase its effectiveness. Achievements in molecular genetic, cytological, immunological and biochemical studies contribute to the development of novel approaches to the diagnosis and treatment of ovarian cancer.Conclusion. With the advent of new novel approaches to the diagnosis and treatment of ovarian cancer, it is becoming increasingly clear that the tumor microenvironment can significantly affect the success of chemotherapy. New biomarkers can help identify the best candidates for ovarian cancer treatment. Further basic and applied research is needed to explore the use of different diagnostic and therapeutic agents in ovarian cancer.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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