2,4-二硝基苯酚能增强顺铂和依托泊苷对前列腺癌细胞株的细胞毒活性

IF 1.3 4区医学 Q4 ENVIRONMENTAL SCIENCES

Annals of Agricultural and Environmental Medicine Pub Date : 2023-11-16 DOI:10.26444/aaem/174919

Grzegorz Adamczuk, E. Humeniuk, Kamila Adamczuk, A. Grabarska, B. Madej-Czerwonka, Mariola Michalczuk, Agnieszka Korga-Plewko, Jarosław Dudka

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引用次数: 0

摘要

简介在晚期癌症治疗方案中加入更多干扰癌细胞能量代谢的化合物，可能是克服耐药性问题和传统化疗药物疗效的一种方法。2,4-DNP（2,4-二硝基苯酚）是一种能使氧化磷酸化脱钩从而改变能量产生途径活性的化合物。研究目的研究的目的是评估 2,4-DNP 能否使前列腺癌细胞对顺铂和依托泊苷的作用敏感，或加强它们的作用。

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2,4-dinitrophenol enhances cisplatin and etoposide cytotoxic activity on prostate cancer cell line

Introduction. Including additional compounds that disturb the energy metabolism of cancer cells in advanced cancer therapy regimens may be an approach to overcome the problem of drug resistance and the therapeutic effectiveness of classic chemotherapeutics. One of the compounds that decouple oxidative phosphorylation, and thus alter the activity of energy-producing pathways, is 2,4-DNP (2,4-dinitrophenol). Objective. The aim of the study was to assess the ability of the 2,4-DNP to sensitize prostate cancer cells to the action of cisplatin and etoposide, or to intensify their action.

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来源期刊

Annals of Agricultural and Environmental Medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.00

自引率

5.90%

发文量

审稿时长

4-8 weeks

期刊介绍： All papers within the scope indicated by the following sections of the journal may be submitted: Biological agents posing occupational risk in agriculture, forestry, food industry and wood industry and diseases caused by these agents (zoonoses, allergic and immunotoxic diseases). Health effects of chemical pollutants in agricultural areas , including occupational and non-occupational effects of agricultural chemicals (pesticides, fertilizers) and effects of industrial disposal (heavy metals, sulphur, etc.) contaminating the atmosphere, soil and water. Exposure to physical hazards associated with the use of machinery in agriculture and forestry: noise, vibration, dust. Prevention of occupational diseases in agriculture, forestry, food industry and wood industry. Work-related accidents and injuries in agriculture, forestry, food industry and wood industry: incidence, causes, social aspects and prevention. State of the health of rural communities depending on various factors: social factors, accessibility of medical care, etc.