保肝植物复方制剂对肼诱发实验性肝病变的实验鼠内源性中毒严重程度的影响

Elena Kuz'minova, Andrey Koschaev, O. Vasiliadi, Marina Petrovna Semenenko, A. Abramov
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摘要

摘要目的是研究保肝植物复方制剂对肼引起实验性肝脏病变的实验鼠内源性中毒严重程度的影响。研究方法。研究对象为非线性大鼠,分为 3 组(n = 10)。第 1 组和第 2 组大鼠的肝脏毒性损害是通过胃内单次注射 200 毫克/千克体重剂量的联氨来模拟的。第 1 组在中毒后立即并在接下来的三周内使用药物 fitosomin--每天口服,剂量为 0.5 克/千克体重;第 2 组在中毒后接受空谷物栓剂;第 3 组保持原样。在动态分析中,通过在 λ = 254 和 280 纳米波长下动物血液中中等质量分子(MMM)的浓度来研究内源性中毒的程度。科学新颖性。通过实验获得了有关保肝植物复合物药理作用的新数据,该复合物包括卵磷脂、双氢槲皮素、奶蓟提取物、苦参提取物和金牛肝菌提取物。首次确定了 fitosomin 药物对减轻肼引起的实验性肝脏病变的实验鼠内源性中毒综合征的严重程度的有效性。研究结果经测定,肼诱发的实验鼠肝脏病变伴随着内源性中毒综合征的发生,相对于 MMM 280,MMM 254 的血液成分增加更为明显。使用 fitosomin 会减弱肼对肝脏和整个动物体的毒性作用。使用保肝植物复合物可提高大鼠的存活率,改善其临床状况,并降低血液中 MMM 的浓度。研究结果概述了在兽医实践中使用fitosomin药物治疗肝损伤和动物中毒的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of the hepatoprotective phytocomplex on the severity of endogenous intoxication in laboratory rats with experimental liver pathology induced by hydrazine
Abstract. The purpose is to study the influence of the hepatoprotective phytocomplex on the severity of endogenous intoxication in laboratory rats with experimental liver pathology caused by hydrazine. Methods. The studies were carried out on non-linear rats, formed into 3 groups (n = 10). Toxic damage to the liver in rats of groups 1 and 2 was modeled by a single intragastric administration of hydrazine at a dose of 200 mg/kg of body weight. Immediately after intoxication and for the next three weeks in 1st group, the drug fitosomin was used – daily orally in the form of boluses at a dose of 0.5 g/kg of body weight, 2nd group after intoxication received empty cereal boluses, 3rd group was intact. In dynamics, the degree of endogenous intoxication was studied by the concentration of medium mass molecules (MMM) in the blood of animals at λ = 254 and 280 nm. Scientific novelty. Experimentally new data on the pharmacological effects of the hepatoprotective phytocomplex was obtained, which includes lecithin, dihydroquercetin, extracts of milk thistle, agrimony and golden boletus. For the first time, the effectiveness of the drug fitosomin was determined to reduce the severity of the endogenous intoxication syndrome in laboratory rats with experimental liver pathology caused by hydrazine. Results. It has been determined that hydrazine-induced liver pathology in laboratory rats is accompanied by the development of endogenous intoxication syndrome with a more pronounced increase in the blood fraction of MMM 254 relative to MMM 280. The use of fitosomin leads to a weakening of the toxic effect of hydrazine both on the liver and on the body of animals as a whole. The course application of the hepatoprotective phytocomplex increases the survival rate of rats, improves their clinical condition and leads to a decrease in the concentration of MMM in the blood. The obtained results outlined the prospects for the use of the drug fitosomin in veterinary practice in case of liver damage, as well as intoxication of animals.
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