{"title":"评估聚乙烯醇/氧化镁仿生复合材料对人类口腔癌细胞的抗癌作用","authors":"Hasti Sarabikia, Razieh Souri, Mohsen Safaei","doi":"10.5812/jkums-140157","DOIUrl":null,"url":null,"abstract":"Background: Oral squamous cell carcinoma (OSCC) represents the most widespread type of squamous cell carcinoma (SCC) in the head and neck region, comprising 90% of all cases of oral cancer. Treatments based on immunological methods, cell therapy, gene therapy, and nanotechnology-based methods have been performed in addition to conventional treatment methods. Objectives: This study aimed to investigate the anticancer effects of polyvinyl alcohol/MgO nanocomposite on human oral cancer cells. Methods: In this study, the structure and size of nanoparticles and nanocomposite were identified using scanning electron microscope (SEM) analysis after synthesizing PVA/MgO nanocomposite. The anticancer activity of the synthesized nanocomposite was investigated against oral cancer cells of KB type. Results: SEM analysis confirmed the proper synthesis of PVA/MgO nanocomposite. MTT test showed that the nanocomposite synthesized in the concentration range of 25-200μl has maximum anticancer properties against KB cancer cells. In addition, PVA/MgO nanocomposite influenced the apoptosis pathway of KB cancer cells by increasing ROS, decreasing mitochondrial membrane potential, and increasing the activities of caspases 3 and 7. Conclusions: Based on the results, the PVA/MgO nanocomposite showed considerable potential as a viable contender for novel anticancer interventions.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluating the Anticancer Effects of Polyvinyl Alcohol/Magnesium Oxide Bionanocomposite on Human Oral Cancer Cells\",\"authors\":\"Hasti Sarabikia, Razieh Souri, Mohsen Safaei\",\"doi\":\"10.5812/jkums-140157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Oral squamous cell carcinoma (OSCC) represents the most widespread type of squamous cell carcinoma (SCC) in the head and neck region, comprising 90% of all cases of oral cancer. Treatments based on immunological methods, cell therapy, gene therapy, and nanotechnology-based methods have been performed in addition to conventional treatment methods. Objectives: This study aimed to investigate the anticancer effects of polyvinyl alcohol/MgO nanocomposite on human oral cancer cells. Methods: In this study, the structure and size of nanoparticles and nanocomposite were identified using scanning electron microscope (SEM) analysis after synthesizing PVA/MgO nanocomposite. The anticancer activity of the synthesized nanocomposite was investigated against oral cancer cells of KB type. Results: SEM analysis confirmed the proper synthesis of PVA/MgO nanocomposite. MTT test showed that the nanocomposite synthesized in the concentration range of 25-200μl has maximum anticancer properties against KB cancer cells. In addition, PVA/MgO nanocomposite influenced the apoptosis pathway of KB cancer cells by increasing ROS, decreasing mitochondrial membrane potential, and increasing the activities of caspases 3 and 7. Conclusions: Based on the results, the PVA/MgO nanocomposite showed considerable potential as a viable contender for novel anticancer interventions.\",\"PeriodicalId\":16201,\"journal\":{\"name\":\"Journal of Kermanshah University of Medical Sciences\",\"volume\":\"48 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Kermanshah University of Medical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5812/jkums-140157\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Kermanshah University of Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5812/jkums-140157","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluating the Anticancer Effects of Polyvinyl Alcohol/Magnesium Oxide Bionanocomposite on Human Oral Cancer Cells
Background: Oral squamous cell carcinoma (OSCC) represents the most widespread type of squamous cell carcinoma (SCC) in the head and neck region, comprising 90% of all cases of oral cancer. Treatments based on immunological methods, cell therapy, gene therapy, and nanotechnology-based methods have been performed in addition to conventional treatment methods. Objectives: This study aimed to investigate the anticancer effects of polyvinyl alcohol/MgO nanocomposite on human oral cancer cells. Methods: In this study, the structure and size of nanoparticles and nanocomposite were identified using scanning electron microscope (SEM) analysis after synthesizing PVA/MgO nanocomposite. The anticancer activity of the synthesized nanocomposite was investigated against oral cancer cells of KB type. Results: SEM analysis confirmed the proper synthesis of PVA/MgO nanocomposite. MTT test showed that the nanocomposite synthesized in the concentration range of 25-200μl has maximum anticancer properties against KB cancer cells. In addition, PVA/MgO nanocomposite influenced the apoptosis pathway of KB cancer cells by increasing ROS, decreasing mitochondrial membrane potential, and increasing the activities of caspases 3 and 7. Conclusions: Based on the results, the PVA/MgO nanocomposite showed considerable potential as a viable contender for novel anticancer interventions.