牙周疫苗:我们的现状与未来

Saksham Kohli, Gunjan Singh, Srishtee Mathur, Pranjal Soni, Marrium Siddqua
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摘要

18 世纪末,爱德华-詹纳(Edward Jenner)利用对人类无害的牛痘病毒提供的交叉保护,设计并确立了疫苗接种的概念。在成年人中,牙周病及其多种微生物病因是导致牙齿脱落的主要原因。目前的治疗方法只能阻止疾病的发展,既不能完全治愈,也不能阻止其复发。因此,需要更先进的治疗方法,其中可能包括针对潜在牙周细菌的疫苗。牙周疫苗是牙周病学的福音。目前还没有一项牙周疫苗研究能够完全满足理想牙周疫苗的所有标准。牙周疫苗接种的目标是找出牙周炎破坏过程中的抗原,从而诱导抗体来预防牙周炎。未来,牙周疫苗可能会成为机械疗法的补充。为了降低与人类牙周病相关的发病率,消除牙周病给全世界带来的负担将是任何牙周疫苗的首要功能。本文将重点介绍牙周病疫苗接种的现有方法,以及就这一问题而言未来可能出现的情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Periodontal vaccines: Where we are now and where we can go
Edward Jenner devised and established the notion of vaccination in the late 18th century, using the cross-protection offered by the cowpox virus, which is not dangerous to humans. In adults, periodontal diseases with their multi-microbial etiology are a leading cause of tooth loss. Current treatment approaches have only been able to stop the disease’s progression; neither do they totally cure the condition nor stop it from returning. As a result, there is a need for more advanced therapeutic approaches, which may include vaccines that target potential periodontal bacteria. A boon to periodontics is the periodontal vaccination. No periodontal vaccine study has been able to fully meet all of the criteria for the ideal periodontal vaccine. The goal of the periodontal vaccination is to pinpoint the antigens implicated in the periodontitis damaging process that antibodies would be induced to guard against. In the future, periodontal vaccinations might become a supplement to mechanical therapy. To reduce the morbidity associated with periodontal disease in humans, eliminating the worldwide burden of periodontal disease would be the demanding primary function of any periodontal vaccination. This paper focuses on bringing to light the current approaches to periodontal vaccinations and what the future might have in store as far as this issue is concerned.
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