将大型蚤作为筛选胆碱能药理物质的试验对象

Journal Biomed Pub Date : 2023-11-20 DOI:10.33647/2713-0428-19-3e-81-84

A. A. Bondarenko, A. S. Melehova, A. Y. Bespalov, T. L. Gorchakova, L. I. Prokopenko

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引用次数: 0

摘要

以大型水蚤 Straus 为实验动物水生动物模型，初步筛选出具有抗惊厥和胆碱阻滞活性的丙戊酸氨基醚类化合物。在此基础上，筛选出最有效的化合物，在温血动物中进行进一步试验。筛选标准包括化合物在预防苯氨基甲酸酯诱发的非典型运动过动症方面的最低有效浓度。

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Daphnia magna Straus as a Test Object for Screening Cholinergic Pharmacological Substances

Daphnia magna Straus was used as an experimental zoohydrobiont model for primary screening of compounds of the valproic acid aminoether group with anticonvulsant and cholinoblocking activity. On this basis, the most effective compounds for further trials in warm-blooded animals were selected. The selection criterion included their minimum effective concentration for the prevention of atypical motor hyperactivity induced by phenylcarbamate.

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Journal Biomed

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