V. Muronetz, Lidia P. Kurochkina, Evgeniia V. Leisi, S. Kudryavtseva
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引用次数: 0
摘要
本综述讨论了消化道微生物群对由朊病毒蛋白或α-突触核蛋白病理转化引起的淀粉样神经退行性疾病的发生所起作用的具体机制。细菌 GroE 伴孢素系统和噬菌体伴孢素(单环 OBP 和双环 EL)对朊病毒蛋白转化的影响已经有所描述。许多研究表明,伴侣素以 ATP 依赖性方式刺激朊病毒蛋白形成细胞毒性淀粉样形式。此外,研究还发现,大肠杆菌细胞裂解物对朊病毒蛋白也有类似的作用,而且淀粉样蛋白的转化效率与细胞中 GroE 的含量有关。研究提供了有关肠道微生物合成的一些代谢物对帕金森病等突触核蛋白病发病的影响的数据。特别是描述了利用微生物群代谢物诱导肠上皮细胞中的α-突触核蛋白发生淀粉样转化,随后在神经组织中形成类似朊病毒的病理形式。研究还考虑了微生物群对淀粉样神经退行性疾病的发生和发展的可能影响机制。
Are Gastrointestinal Microorganisms Involved in the Onset and Development of Amyloid Neurodegenerative Diseases?
This review discusses a few examples of specific mechanisms mediating the contribution of the GIT microbiota to the development of amyloid neurodegenerative diseases caused by the pathologic transformation of prion protein, or alpha-synuclein. The effect of the bacterial GroE chaperonin system and phage chaperonins (single-ring OBP and double-ring EL) on prion protein transformation has been described. A number of studies have shown that chaperonins stimulate the formation of cytotoxic amyloid forms of prion protein in an ATP-dependent manner. Moreover, it was found that E. coli cell lysates have a similar effect on prion protein, and the efficiency of amyloid transformation correlates with the content of GroE in cells. Data on the influence of some metabolites synthesized by gut microorganisms on the onset of synucleinopathies, such as Parkinson’s disease, is provided. In particular, the induction of amyloid transformation of alpha-synuclein from intestinal epithelial cells with subsequent prion-like formation of its pathologic forms in nervous tissues featuring microbiota metabolites is described. Possible mechanisms of microbiota influence on the occurrence and development of amyloid neurodegenerative diseases are considered.
期刊介绍:
Microbiology Research is an international, online-only, open access peer-reviewed journal which publishes original research, review articles, editorials, perspectives, case reports and brief reports to benefit researchers, microbiologists, physicians, veterinarians. Microbiology Research publishes ‘Clinic’ and ‘Research’ papers divided into two different skill and proficiency levels: ‘Junior’ and ‘Professional’. The aim of this four quadrant grid is to encourage younger researchers, physicians and veterinarians to submit their results even if their studies encompass just a limited set of observations or rely on basic statistical approach, yet upholding the customary sound approach of every scientific article.