激活海马区的神经发生是阿尔茨海默病的新型治疗靶点

Neuroprotection Pub Date : 2023-11-21 DOI:10.1002/nep3.25

Akihiko Taguchi, Yuka Okinaka, Akiko Takeda, Takayuki Okamoto, Johannes Boltze, Carsten Claussen, Sheraz Gul

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引用次数: 0

摘要

针对大脑生理（衰老）和病理（神经变性）功能丧失的单一机制可能是不够的。移植的成体干细胞与常驻细胞之间通过间隙连接进行的细胞-细胞相互作用，有可能支持衰老或病变的大脑。这些细胞-细胞相互作用还能增加海马神经发生。这可能是治疗阿尔茨海默氏症和其他神经退行性疾病的一种新型治疗策略，可与任何已有的治疗方法同时使用。

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Activation of neurogenesis in the hippocampus is a novel therapeutic target for Alzheimer's disease

Targeting single mechanisms of physiological (aging) and pathological (neurodegeneration) loss of function in the brain may not be sufficient. Cell–cell interactions between transplanted adult stem cells and resident cells via gap junctions have the potential to support the aging or diseased brain. These cell–cell interactions can also increase hippocampal neurogenesis. This may be a novel therapeutic strategy for Alzheimer's disease and other neurodegenerative diseases that could be applied alongside any established treatments.

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Neuroprotection

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