细胞周期协调维持弧菌双组基因组

Q1 Medicine

EcoSal Plus Pub Date : 2023-11-22 DOI:10.1128/ecosalplus.esp-0008-2022

Théophile Niault, Jakub Czarnecki, Morgan Lambérioux, D. Mazel, Marie-Eve Val

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引用次数: 0

摘要

摘要为了保持基因组的完整性，细菌依赖于与细胞周期相协调的几种基因组维护机制。弧菌家族的所有成员都有一个由主染色体（Chr1）和次染色体（Chr2）组成的双部分基因组，主染色体与大肠杆菌等其他细菌的单条染色体同源，次染色体则由共同祖先以质粒形式获得。在这篇综述中，我们将介绍目前对霍乱弧菌基因组维护的理解，霍乱弧菌是多部分基因组细菌的最佳研究模型。在简要概述了霍乱弧菌基因组结构的多样性之后，我们描述了控制霍乱弧菌两条染色体复制和分离的特殊、共同和协调机制。我们特别关注了使 Chr1 和 Chr2 复制同步的独特检查点机制。

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Cell cycle-coordinated maintenance of the Vibrio bipartite genome

ABSTRACT To preserve the integrity of their genome, bacteria rely on several genome maintenance mechanisms that are co-ordinated with the cell cycle. All members of the Vibrio family have a bipartite genome consisting of a primary chromosome (Chr1) homologous to the single chromosome of other bacteria such as Escherichia coli and a secondary chromosome (Chr2) acquired by a common ancestor as a plasmid. In this review, we present our current understanding of genome maintenance in Vibrio cholerae, which is the best-studied model for bacteria with multi-partite genomes. After a brief overview on the diversity of Vibrio genomic architecture, we describe the specific, common, and co-ordinated mechanisms that control the replication and segregation of the two chromosomes of V. cholerae. Particular attention is given to the unique checkpoint mechanism that synchronizes Chr1 and Chr2 replication.

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来源期刊

EcoSal Plus Immunology and Microbiology-Microbiology

CiteScore

12.20

自引率

0.00%

发文量

期刊介绍： EcoSal Plus is the authoritative online review journal that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This journal is intended primarily for the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell. Thoughtful reviews focus on physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history E. coli and its relatives. These provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Articles contain links to E. coli K12 genes on the EcoCyc database site and are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files.