T. D. Solntseva, O. Sivakova, A. Aksenova, I. Chazova
{"title":"未受控制的动脉高血压患者的抗高血压治疗和服药依从性","authors":"T. D. Solntseva, O. Sivakova, A. Aksenova, I. Chazova","doi":"10.38109/2225-1685-2023-4-24-30","DOIUrl":null,"url":null,"abstract":"Aim. To evaluate the antihypertensive therapy and adherence to treatment in patients with uncontrolled arterial hypertension.Materials and Мethods. The study included 297 patients hospitalized at the E.I. Chazov National Medical Research Center of Cardiology over the period from September 2019 to March 2022. Patients were spread into two groups depending on the increase in the frequency of BP: group 1 (n=149) – increase in BP above 140/90 mm Hg 1 or more per week while taking antihypertensive therapy with clinical manifestations, and group 2 (n=148) – increase in blood pressure more than 140/90 mm Hg less than 1 per week while taking antihypertensive therapy clinical manifestations. Antihypertensive therapy and medication adherence were assessed at hospital discharge and after 12 months.Results. Initially, the number of antihypertensive drugs was greater in patients with group 1 versus the patients with group 2 (p<0,001). The frequency of taking antihypertensive therapy initially and after 12 months was greater in group 1 (p<0,001). After 12 months, the number of antihypertensive drugs decreased in the group 1, and remained the same in group 2. When comparing the different classes of antihypertensive drugs, all classes, except angiotensin-converting enzyme inhibitors were most frequently prescribed in group 1 (p<0,05). After 12 months, a lower level of adherence was observed in group 1 patients compared to group 2 (6 [5-8] points vs. 8 [6-9] points) (p<0,001), as evidenced in the reduced intake of different classes of antihypertensive therapy.Conclusion. Uncontrolled arterial hypertension is a release of hypertension associated with more antihypertensive medications to be prescribed and adherence to be monitored more closely.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":"64 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antihypertensive therapy and medication adherence in patients with uncontrolled arterial hypertension\",\"authors\":\"T. D. Solntseva, O. Sivakova, A. Aksenova, I. Chazova\",\"doi\":\"10.38109/2225-1685-2023-4-24-30\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim. To evaluate the antihypertensive therapy and adherence to treatment in patients with uncontrolled arterial hypertension.Materials and Мethods. The study included 297 patients hospitalized at the E.I. Chazov National Medical Research Center of Cardiology over the period from September 2019 to March 2022. Patients were spread into two groups depending on the increase in the frequency of BP: group 1 (n=149) – increase in BP above 140/90 mm Hg 1 or more per week while taking antihypertensive therapy with clinical manifestations, and group 2 (n=148) – increase in blood pressure more than 140/90 mm Hg less than 1 per week while taking antihypertensive therapy clinical manifestations. Antihypertensive therapy and medication adherence were assessed at hospital discharge and after 12 months.Results. Initially, the number of antihypertensive drugs was greater in patients with group 1 versus the patients with group 2 (p<0,001). The frequency of taking antihypertensive therapy initially and after 12 months was greater in group 1 (p<0,001). After 12 months, the number of antihypertensive drugs decreased in the group 1, and remained the same in group 2. When comparing the different classes of antihypertensive drugs, all classes, except angiotensin-converting enzyme inhibitors were most frequently prescribed in group 1 (p<0,05). After 12 months, a lower level of adherence was observed in group 1 patients compared to group 2 (6 [5-8] points vs. 8 [6-9] points) (p<0,001), as evidenced in the reduced intake of different classes of antihypertensive therapy.Conclusion. Uncontrolled arterial hypertension is a release of hypertension associated with more antihypertensive medications to be prescribed and adherence to be monitored more closely.\",\"PeriodicalId\":11859,\"journal\":{\"name\":\"Eurasian heart journal\",\"volume\":\"64 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eurasian heart journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.38109/2225-1685-2023-4-24-30\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eurasian heart journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.38109/2225-1685-2023-4-24-30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的评估未得到控制的动脉高血压患者的降压治疗和治疗依从性。研究对象包括2019年9月至2022年3月期间在国家心脏病学医学研究中心(E.I. Chazov National Medical Research Center of Cardiology)住院的297名患者。根据血压升高的频率将患者分为两组:第1组(n=149)--每周1次或1次以上血压升高超过140/90毫米汞柱,同时服用抗高血压治疗药物有临床表现;第2组(n=148)--每周1次以下血压升高超过140/90毫米汞柱,同时服用抗高血压治疗药物有临床表现。出院时和12个月后对抗高血压治疗和用药依从性进行评估。最初,第一组患者服用的降压药物数量多于第二组患者(P<0.001)。最初和 12 个月后,1 组患者服用降压药的频率更高(P<0.001)。12 个月后,第 1 组患者服用降压药的次数减少,而第 2 组保持不变。 比较不同类别的降压药,除血管紧张素转换酶抑制剂外,第 1 组患者服用所有类别降压药的次数最多(P<0.05)。12 个月后,观察到第 1 组患者的依从性低于第 2 组(6 [5-8] 分对 8 [6-9] 分)(p<0,001),这从不同类别降压药的摄入量减少中可见一斑。结论:未得到控制的动脉高血压是高血压的一种释放,需要处方更多的降压药物,并对患者的依从性进行更密切的监测。
Antihypertensive therapy and medication adherence in patients with uncontrolled arterial hypertension
Aim. To evaluate the antihypertensive therapy and adherence to treatment in patients with uncontrolled arterial hypertension.Materials and Мethods. The study included 297 patients hospitalized at the E.I. Chazov National Medical Research Center of Cardiology over the period from September 2019 to March 2022. Patients were spread into two groups depending on the increase in the frequency of BP: group 1 (n=149) – increase in BP above 140/90 mm Hg 1 or more per week while taking antihypertensive therapy with clinical manifestations, and group 2 (n=148) – increase in blood pressure more than 140/90 mm Hg less than 1 per week while taking antihypertensive therapy clinical manifestations. Antihypertensive therapy and medication adherence were assessed at hospital discharge and after 12 months.Results. Initially, the number of antihypertensive drugs was greater in patients with group 1 versus the patients with group 2 (p<0,001). The frequency of taking antihypertensive therapy initially and after 12 months was greater in group 1 (p<0,001). After 12 months, the number of antihypertensive drugs decreased in the group 1, and remained the same in group 2. When comparing the different classes of antihypertensive drugs, all classes, except angiotensin-converting enzyme inhibitors were most frequently prescribed in group 1 (p<0,05). After 12 months, a lower level of adherence was observed in group 1 patients compared to group 2 (6 [5-8] points vs. 8 [6-9] points) (p<0,001), as evidenced in the reduced intake of different classes of antihypertensive therapy.Conclusion. Uncontrolled arterial hypertension is a release of hypertension associated with more antihypertensive medications to be prescribed and adherence to be monitored more closely.