心血管疾病中的辅酶 q10:潜在治疗功效的启示

Amit Zinabhai Chaudhari, Riyansi Satasia, Maulikkumar D. Vaja, Kishan Patel
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摘要

人体可合成维生素辅酶 Q10(CoQ10),它在电子传递链中发挥着至关重要的作用,可确保持续、充足的能量供应。辅酶 Q10 在细胞中发挥多种作用,包括参与线粒体功能、多个细胞区和血浆脂蛋白。此外,CoQ10 还是一种重要的抗氧化剂。CoQ10 的化学成分与维生素 K 密切相关,它由一个苯醌环作为头部基团,尾部由十个异戊二烯单位组成。CoQ10 的缺乏已被认为是导致许多与年龄有关的疾病和慢性疾病的根本原因。CoQ10 对各种病症的疗效已得到经验证据的证实。目前,许多研究试验正在调查 CoQ10 的治疗和营养潜力。CoQ10 仍主要用于心脏研究和生殖治疗领域。不过,人们对探索新应用的兴趣明显增加,特别是在局部用药方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coenzyme q10 in cardiovascular disease: an insight for a potential therapeutic benefit
The human body synthesizes the provitamin coenzyme Q10 (CoQ10), which plays a crucial role in the electron transport chain by ensuring a consistent and sufficient energy supply. CoQ10 exhibits multiple cellular roles, including its involvement in mitochondrial function, numerous cellular compartments, and plasma lipoproteins. Furthermore, CoQ10 plays a crucial role as an important antioxidant. The chemical composition of CoQ10 exhibits a strong correlation with vitamin K. It consists of a benzoquinone ring serving as the head group, accompanied by a tail made of ten isoprene units. A lack of CoQ10 has been identified as a fundamental factor contributing to numerous age-related and chronic illness problems. The efficacy of CoQ10 in various medical conditions has been proved by empirical evidence. Numerous research trials are now investigating the therapeutic and nutritional potential of CoQ10. CoQ10 continues to be predominantly utilized in the realm of cardiac research and reproductive treatments. However, there has been a notable surge of interest in exploring novel applications, notably in the context of topical administration.
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