青少年特发性脊柱侧凸的后路脊柱融合术以及术后静脉注射地塞米松的影响

Amy McIntosh, Emily Lachmann, Anne‐Marie Datcu, Christopher McLeod
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摘要

对接受脊柱后路融合术的青少年特发性脊柱侧凸患者实施的术后护理路径已证明可减少术后阿片类药物的用量、改善疼痛控制并缩短住院时间。我们的目标是在术后使用类固醇,以减少术后阿片类药物的急性用量、疼痛评分和住院时间。剂量包括静脉注射地塞米松 0.1 毫克/千克,每次剂量最多 4 毫克,术后 8、16 和 24 小时共注射三次。作为质量计划的一部分,我们对三组患者进行了比较。最初的回顾性硬膜外队列(EPI)(n = 59)由外科医生置入硬膜外导管,术后输注 0.1% 罗哌卡因 18-24 小时。第二组患者(n = 149)接受了外科医生置入的竖脊平面阻滞,并在伤口处浸润了脂质体和普通布比卡因(LB)。第三个组群(n = 168)接受了前瞻性评估。该组患者接受了外科医生放置的直立肌脊柱平面阻滞和伤口浸润脂质体及普通布比卡因,术后还接受了三剂地塞米松(LB + D)。与LB组相比,LB + D组在0-24小时、24-48小时和48-72小时的每公斤口服毫克吗啡当量均有统计学意义上的显著下降,LB + D组在24-48小时和48-72小时的中位疼痛评分与LB组相比有统计学意义上的显著差异。枸橼酸+D组的中位住院时间(以小时计)明显少于枸橼酸组(52小时对70小时,P < 0.0001)。在特发性脊柱侧凸后路脊柱融合术患者的既定术后护理路径中加入术后静脉注射地塞米松,可降低VAS疼痛评分、减少阿片类药物用量并缩短住院时间。
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Posterior spinal fusion for adolescent idiopathic scoliosis and the impact of postoperative intravenous dexamethasone supplementation
Postoperative care pathways for adolescent idiopathic scoliosis patients undergoing posterior spinal fusion have demonstrated decreases in postoperative opioid consumption, improved pain control, and lead to decreased lengths of stay. Our objective was to implement postoperative steroids to reduce acute postoperative opioid consumption, pain scores, and length of stay. Dosing consisted of intravenous dexamethasone 0.1 mg/kg up to 4 mg per dose for a total of three doses at 8, 16, and 24 h postoperatively. As part of a quality initiative, we compared three cohorts of patients. The initial retrospective epidural cohort (EPI) (n = 59) had surgeon placed epidural catheters with infusion of ropivacaine 0.1% postoperatively for 18–24 h. Following an institutional change in postoperative care, epidural use was discontinued. A second cohort (n = 149), with prospectively collected data, received a surgeon placed erector spinae plane block and wound infiltration with a combination of liposomal and plain bupivacaine (LB). A third cohort (n = 168) was evaluated prospectively. This cohort received a surgeon placed erector spinae plane block and wound infiltration with liposomal and plain bupivacaine and additionally received postoperative dexamethasone for three doses (LB + D). Compared to the LB cohort, the LB + D cohort demonstrated statistically significant decreases in oral milligram morphine equivalents per kilogram at 0–24, 24–48, and 48–72 h. There was a statistically significant difference in median pain scores at 24–48 and 48–72 h in LB + D versus LB. The LB + D cohort's median length of stay in hours was significantly less compared to the LB cohort (52 h vs. 70 h, p < 0.0001). Postoperative intravenous dexamethasone was added to an established postoperative care pathway for patients undergoing posterior spinal fusion for idiopathic scoliosis resulting in decreased VAS pain scores, opioid consumption, and shorter length of stay.
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