印度东部一家三级医院 2021 年 4 月至 5 月第二波与 2021 年 12 月至 2022 年 1 月第三波新生儿 SARS-COV2 临床表现和预后的比较

International Journal of Contemporary Pediatrics Pub Date : 2023-11-27 DOI:10.18203/2349-3291.ijcp20233601

Bhaswati Ghoshal, Akhila Andra

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引用次数: 0

摘要

背景：比较了 2021 年 4 月至 5 月（第二波）和 2021 年 12 月至 2022 年 1 月（第三波）两个高峰期新生儿的 SARS-COV-2 表现。研究地点研究在印度东部的三级医疗中心加尔各答国立医学院进行。研究方法在 COVID 指定的新生儿重症监护室收治的新生儿病例中进行横断面研究。新生儿在出生后感染 COVID-19。所有母亲在分娩时均检测为阴性。研究结果COVID 指定新生儿重症监护室在 2021 年 4 月至 5 月接收了 40 名新生儿，在 12 月至 2022 年 1 月接收了 42 名新生儿。与 2021 年 4 月至 5 月的 49.3% 的母亲相比，2022 年 12 月至 1 月的病例中有 66.6% 的母亲 COVID-19 RTPCR 呈阳性。这些母亲在分娩时被检测为 COVID-19 阴性。在 2021 年的病例中，没有一位母亲接种过疫苗。在 2022 年 12 月至 1 月的病例中，只有 13.3% 的母亲接种了两剂 COVID-19 疫苗。在 12 月至 22 年 1 月的病例中，最初的主诉是嗜睡、不能唤醒（22.7%）和呼吸困难（27.5%）。与 2022 年 1 月入院的新生儿相比，2021 年 4 月至 5 月入院的新生儿主要出现呼吸道症状（呼吸急促 40%）和胃肠道症状（腹泻 25.3%）。2022 年 12 月至 1 月入院的新生儿住院时间明显较短（P=0.005）。基因组测序显示，2022 年 1 月的新生儿感染了 Omicron BA-2。结论2021年4月至5月和2022年12月至1月的新生儿临床表现不同，这可能是由于病毒的性质不同。

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Comparison of clinical presentation and outcome of neonatal SARS-COV2 during second wave from April-May 2021 and third wave from December 2021 to January 2022 in a tertiary care hospital in Eastern India

Background: SARS-COV-2 manifestations in neonates acquired in the later part of neonatal life, were compared over 2 peaks over April-May 2021 (2nd wave) and (December 2021 to January 2022) (3rd wave). Setting: Study was done in Calcutta National Medical College, a tertiary care center of eastern India. Methods: Cross sectional study was done among the admitted neonatal cases in COVID designated NICU. Neonates acquired the COVID-19 infection after birth. All mothers were tested negative during delivery. Results: 40 neonates were admitted in April-May 2021 in COVID designated NICU and 42 neonates were admitted in December to January 2022. 66.6% mothers were COVID-19 RTPCR positive in December-January 2022 cases than 49.3% mothers in April-May 2021. These mothers were tested as COVID-19 negative at the time of delivery. None of the mothers were vaccinated in 2021 cases. Only 13.3% mothers received two doses of COVID-19 vaccination in December-January 2022 cases. Initial complaints were lethargic, not arousable (22.7%) and poor respiratory effort (27.5%) in December-January 22 cases. Respiratory (rapid breathing 40%) and gastrointestinal symptoms (diarrhoea 25.3%) were more predominant in neonates who were admitted in April-May 2021 than neonates who presented on January 2022. Hospital stay was significantly less in neonates in December-January 2022 (p=0.005). Genome sequencing revealed Omicron BA-2 in January 2022. Conclusions: Clinical presentations differ in neonates in April-May 2021 and December-January 2022 probably due to difference in the nature of the virus.

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International Journal of Contemporary Pediatrics

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