甲基苯丙胺中毒脑温平衡评估

D. Cheboksarov, M. V. Petrova, O. V. Strunin, O. V. Ryzhova, O. P. Artyukov, S. Petrikov
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摘要

背景。甲基苯丙胺会对小胶质细胞产生负面影响,减少多巴胺的再摄取,从而导致神经毒性和脑温升高。为了监测脑温的动态变化,可以使用记录头部深层组织热辐射的射线温度计(磁共振温度计)。研究目的:研究急性甲基苯丙胺中毒时的脑温平衡。所有小组均由右撇子男性组成。对照组(I 组)包括 30 名未使用精神活性物质的志愿者(年龄 27 [23-36] 岁)。第二组包括急性甲基苯丙胺中毒的志愿者(n = 15)(年龄 32 [24-40] 岁),他们在病情稳定之前一直接受动态脑温测量。在第二组患者中,磁共振体温测量是在中毒后的头 2 个小时以及入院后的第 1、2、3、4、5 和 7 天进行的。结果显示与未上瘾的参与者相比,上瘾者左半球的磁共振体温明显升高了 0.4°C [95 % CI 0.3-0.6 (p <0.001)],右半球的磁共振体温明显升高了 0.3°C [95 % CI 0.3-0.4 (p <0.001)]。比较第二组在静息状态下的一般脑温变化系数,在统计上显著增加了 1.52 % (95 % CI 0.99-1.62, p = 0.006),随后在吸食甲基苯丙胺后几乎恢复正常[1.36 % (1.36-2.22) (p = 0.508)]。在中毒期间,大脑半球升温 0.7 °C [95 % CI 0.7; 0.7 (p < 0.001)]。同时,第二组的体温变异系数与健康人的体温变异系数在统计学上没有显著差异。结论精神科医生和神经生理学家在研究甲基苯丙胺对大脑器官和功能的影响时所获得的数据证实了我们的研究结果。所获得的数据使我们有可能使用磁共振测温法作为一种方法,对因吸食甲基苯丙胺而出现精神运动变化的大脑状况进行快速和补充诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of cerebral temperature balance in methamphetamine poisoning
Background. Methamphetamine negatively affects microglia, reducing the reuptake of dopamine, which leads to neurotoxicity and an increase in brain temperature. In order to monitor the dynamics of the cerebral temperature, radiothermographs that register the thermal radiation of the deep tissues of the head (MR thermometry) can be used. The purpose of the research: to study the temperature balance of the brain in acute methamphetamine poisoning.Materials and methods. All groups consisted of dextral (right-handed) males. The control group (group I) included 30 volunteers who did not use psychoactive substances (aged 27 [23–36] years). Group II comprised volunteers (n = 15) with acute methamphetamine poisoning (aged 32 [24–40] years), who had their cerebral temperature measured in dynamics until their condition stabilized. In group II patients, MR thermometry was performed during the first 2 hours from the moment of poisoning and on the 1st, 2nd, 3rd, 4th, 5th, and 7th day after admission to the hospital. Results. In the addicted participants without intoxication, the MR temperature of the left hemisphere is statistically significantly higher by 0.4°C [95 % CI 0.3–0.6 (p <0.001)], and of the right hemisphere — by 0.3°C [95 % CI 0.3–0.4 (p <0.001)] compared with that of the participants without addiction. When comparing the coefficient of variation of cerebral temperature in general in group II at rest, there is a statistically significant increase of 1.52 % (95 % CI 0.99–1.62, p = 0.006), followed by a return to almost normal after methamphetamine use [1.36 % (1.36–2.22) (p = 0.508)]. During intoxication, the hemispheres warm up by 0.7 °C [95 % CI 0.7; 0.7 (p < 0.001)]. Meanwhile, the temperature variation coefficient in group II does not show a statistically significant difference from the temperature variation coefficient of healthy individuals. Conclusion. Our results are confirmed by the data obtained by psychiatrists and neurophysiologists investigating the effect of methamphetamine on the brain both organically and functionally. The obtained data make it possible to use MR thermometry as a method of rapid and additional diagnosis of brain conditions manifested by psychomotor changes associated with the use of methamphetamine.
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