亚美尼亚癌症患儿感染 COVID-19:整个流行病期间的报告

Q4 Medicine
I. Melnichenko, R. Papyan, Y. Margaryan, E. Minasyan, S. Hovhannisyan, M. Minasyan, M. Petrosyan, L. Hambardzumyan, H. Grigoryan, S. Hovsepyan, L. Krmoyan, L. Hakobyan, S. Iskanyan, S. Danielyan, L. Vagharshakyan, N. Azizyan, M. Grigoryan, S. Atoyan, G. Tamamyan, L. Sargsyan
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引用次数: 0

摘要

背景和目的。与其他儿童相比,免疫力低下的儿童癌症患者更容易发生严重的 COVID-19 感染。在一项涉及 1500 名儿童癌症患者的 COVID-19 全球登记研究中,20% 的病例发现了严重的危重感染。死亡率为 4%,高于普通儿童的死亡率。有关 COVID-19 在儿童癌症患者中的并发症发生情况的数据仍然有限,而且不同国家的数据也不尽相同。本研究旨在描述亚美尼亚癌症儿童中 COVID-19 感染的发生率和特征。该中心是亚美尼亚唯一一家儿科血液学/肿瘤学机构,位于Yeolyan血液学中心的亚美尼亚儿科癌症和血液疾病中心。2020年6月至2022年3月期间,我们对亚美尼亚的201名癌症患儿进行了研究,其中35例确诊感染了COVID-19。中位年龄为 8.4 岁,男女比例为 1.3。在 COVID-19 阳性患者中,15 人患有急性淋巴细胞白血病,5 人患有淋巴瘤,4 人患有神经母细胞瘤,髓母细胞瘤、横纹肌肉瘤和尤文肉瘤各 2 人。骨肉瘤、急性髓性白血病和恶性三联瘤只有一例。20 名患者(57%)无症状,其余患者表现为发热、咽痛和咳嗽。在血液恶性肿瘤患者中,有四名患者出现了肺炎,其中两名患者随后出现了癌症进展。此外,四名患者出现全血细胞减少/血小板减少,这可能是由于在上述期间的最后三个月感染了奥米克龙。总的来说,COVID-19 并发症的发生率为 11%,死亡率为零。这是亚美尼亚第一份关于癌症儿童 COVID-19 的全国性报告。研究结果表明,与全球估计值相比,严重感染率和死亡率较低。今后还将开展更多研究来探讨这些差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19 infection in children with cancer in Armenia: report for the whole pandemic period
Background and aims. Immunocompromised pediatric patients with cancer are more susceptible to experiencing severe COVID-19 infection compared to other children. In a global registry study of childhood cancer with COVID-19, involving 1500 patients, severe of critical infections were detected in 20 % of the cases. The mortality rate of 4 % excelled that of the general pediatric population. Data about the development of COVID-19 complications in children with cancer remains limited and varies across different countries. This study aims to describe the incidence and characteristics of COVID-19 infection in children with cancer in Armenia.Methods. A prospective analysis was conducted on PCR-confirmed cases of COVID-19 infection in children with cancer aged 0–18 years from 2020 to 2022 at the Pediatric Cancer and Blood Disorders Center of Armenia, Yeolyan Hematology Center, the only pediatric hematology/ oncology institution in our country.Results. Between June 2020 and March 2022, we studied 201 children with cancer in Armenia, of whom 35 cases of COVID-19 infection were confirmed. The median age was 8.4, and the male/female ratio was 1.3. Among the COVID-19-positive patients, 15 had acute lymphoblastic leukemia, 5 had lymphomas, 4 patients had neuroblastoma, and 2 each had medulloblastoma, rhabdomyosarcoma and Ewing sarcoma. There were single cases of osteosarcoma, acute myeloid leukemia and malignant triton tumor. Twenty patients (57 %) were asymptomatic, and the rest presented with fever, sore throat, and cough. Among the patients with hematological malignancies, four developed pneumonia, and two of them experienced cancer progression subsequently. Additionally, four patients had pancytopenia/thrombocytopenia, likely due to the infection with the Omicron in the last three months of the mentioned period. Overall, the incidence of COVID-19 complications was 11 %, and mortality was zero.Conclusion. This is the first nationwide report on COVID-19 in children with cancer in Armenia. The findings indicate lower rates of severe infection and mortality among compared to global estimates. Further studies are emerging to explore these differences.
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来源期刊
Russian Journal of Pediatric Hematology and Oncology
Russian Journal of Pediatric Hematology and Oncology Medicine-Pediatrics, Perinatology and Child Health
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0.40
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36
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