在培养皿中模拟阿尔茨海默病--剖析人类神经元中的淀粉样蛋白-β代谢过程

Q4 Neuroscience

Neuronal signaling Pub Date : 2023-11-28 DOI:10.1042/ns20230020

Elizabeth Hill, Thomas J Cunningham

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引用次数: 0

摘要

本科学评论引用了 Rowland 等人 (https://doi.org/10.1042/NS20230016) 的文章《抑制人类神经元中的胰岛素降解酶可促进淀粉样蛋白-β沉积》。胰岛素降解酶（IDE）和肾蛋白酶（NEP）被认为是两种Aβ降解酶，并得到了人类遗传学和体内数据的支持。Rowland 等人提供了补充证据，证明在人类诱导多能干细胞（iPSC）衍生的皮质神经元中，IDE 在 Aβ 代谢中发挥着关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Modelling Alzheimer’s disease in a Dish – Dissecting Amyloid-β Metabolism in Human Neurons

This scientific commentary refers to ‘Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition’ by Rowland et al. (https://doi.org/10.1042/NS20230016). Insulin-degrading enzyme (IDE) and neprilysin (NEP) have been proposed as two Aβ-degrading enzymes supported by human genetics and in vivo data. Rowland et al. provide complementary evidence of a key role for IDE in Aβ metabolism in human induced pluripotent stem cell (iPSC)-derived cortical neurons.

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来源期刊

Neuronal signaling

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

14 weeks