输血依赖型地中海贫血患者的免疫系统与铁蛋白水平之间的关系:一项回顾性单中心研究

C. Selim
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引用次数: 0

摘要

目的:地中海贫血症是一种遗传性贫血,其特征是ˋ-或ß-球蛋白基因表达减少或缺失(1)。输血依赖型地中海贫血(TDT)导致严重感染的风险增加,这表明该病存在根本性缺陷:研究纳入了 61 名年龄在 18 岁至 45 岁之间的 TDT 患者,他们于 2018 年至 2023 年期间在我们三级医疗中心的血液科门诊接受了随访。为了测定单核细胞表面标志物,按照标准程序处理外周血,用CD4、CD8、CD3、CD19和CD56特异性单克隆抗体标记,并用FACScan流式细胞仪(Sysmex UF 1600)进行细胞荧光分析。 结果在我们的研究中,通过检测淋巴细胞标记物 CD4、CD8、CD3、CD19 和 CD56 的值来评估被诊断为 TDT 患者的免疫系统,结果发现这些值与患者的年感染频率和平均铁蛋白值之间没有显著相关性。结论:61 名患者的平均年龄为(24.83±6.02)岁,其中女性 33 人,男性 28 人。铁蛋白平均值为(3150.88±2553.51)纳克/毫升,转铁蛋白饱和度为(42.42±14.43)。平均每年输血次数为(15.39±1.90)次,平均每年可检测到的感染次数为(2.85±2.02)次。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The relationship between immunologic system and ferritin levels in patients with transfusion dependent thalassemia: a retrospective single-center study
Aims: Thalassemia is an inherited anemia characterized by reduced or absent expression of ?- or ß-globulin genes (1). Transfusion dependent thalassemia (TDT) has an increased risk for serious infections, suggesting that a fundamental defect Methods: The study included 61 patients with TDT between the ages of 18 and 45 who were followed up in the hematology clinic of our tertiary care center between 2018 and 2023. For the determination of mononuclear cell surface markers, peripheral blood was processed according to standard procedures, labeled with monoclonal antibodies specific for CD4, CD8, CD3, CD19, and CD56, and analyzed by cytofluorometric analysis with a FACScan flow cytometer (Sysmex UF 1600). Results: In our study, CD4, CD8, CD3, CD19, and CD56 values, which are lymphocyte markers, were examined to evaluate the immune system of patients diagnosed with TDT, and it was observed that there was no significant correlation between these values and the annual infection frequency and mean ferritin values of the patients. Conclusion : The mean age of the 61 patients included in the study was 24.83±6.02 years, and 33 were female and 28 were male. The mean ferritin value was 3150.88±2553.51 ng/ml, and transferrin saturation was 42.42±14.43. The mean number of transfusions per year was 15.39±1.90, and the mean number of detectable infections per year was 2.85±2.02.
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