功能医学对甲状腺功能减退症的管理

Chun-Muk Park
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摘要

甲状腺功能减退症是指甲状腺不能产生足够的甲状腺激素来维持正常的身体活动。常见原因包括桥本氏甲状腺炎等自身免疫性疾病、手术切除甲状腺和放射治疗。它表现出多种临床症状,包括皮肤干燥、浮肿、不耐寒、思维迟钝和体重增加。然而,有些患者在单独使用甲状腺功能减退症的标准治疗药物LT4(左甲状腺素)后症状并没有得到充分改善。随着我们对甲状腺生理学认识的不断深入,单用LT4治疗期间出现不适的原因也逐渐明朗,其中包括T4(甲状腺素)向T3(三碘甲状腺原氨酸)的外周转化问题、脱碘酶和甲状腺激素转运体的基因突变,以及甲状腺激素耐药性的研究。本文将介绍每种甲状腺激素制剂的特点、甲状腺功能减退症的传统治疗方法以及甲状腺生理学,并介绍在治疗单用LT4治疗无改善的患者时,LT3(甲状腺素)和功能医学方法及治疗的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management to hypothyroidism in functional medicine
Hypothyroidism is a condition in which the thyroid gland does not produce enough thyroid hormones to maintain normal physical activity. Common causes include autoimmune diseases such as Hashimoto's thyroiditis, surgical removal of the thyroid gland, and radiation therapy. It presents with a variety of clinical symptoms, including dry skin, puffiness, intolerance to cold, slowed thinking, and weight gain. However, there are patients who do not show sufficient symptom improvement with LT4 (levothyroxine) alone, the standard treatment for hypothyroidism. As our understanding of thyroid physiology advances, the reasons for discomfort during LT4 monotherapy are becoming clear, including problems with peripheral conversion of T4 (thyroxine) to T3 (triiodothyronine), genetic mutations in deiodinase and thyroid hormone transporter, and thyroid hormones resistance has been studied. In this article, we will look into the characteristics of each thyroid hormone preparation, conventional treatment on hypothyroidism, and thyroid physiology, and present the necessity of LT3 (liothyronine) and functional medicine approach and treatment when treating patients who do not improve with LT4 treatment alone.
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