罗马尼亚穆雷什县具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤(NIFTP):六年期间(2016-2021年)的发病率和重新分类的影响

Q4 Pharmacology, Toxicology and Pharmaceutics
A. Nechifor-Boilă, Ancuța Cota, E. Szász, R. Cătană, Angela Borda
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引用次数: 0

摘要

摘要 目的:2016年,一组内分泌病理专家为甲状腺癌的组织学亚型(甲状腺乳头状癌的包膜滤泡变异型,非侵袭性类型)提出了一个新术语--NIFTP(具有乳头状核特征的非侵袭性滤泡型甲状腺肿瘤)。在本研究中,我们旨在以回顾性的方式评估罗马尼亚穆雷县六年内(2016-2021 年)NIFTP 的流行趋势和总体发病率。研究方法:对 2016-2021 年间在塔尔古-穆雷什病理科登记的所有 NIFTP 进行重新评估。NIFTP发病率的计算方法是将NIFTP的数量除以甲状腺乳头状癌(PTC)的数量。此外,由于NIFTP的诊断标准在2018年进行了修订,我们将2016-2018年间的NIFTP发病率与2019-2021年间的NIFTP发病率进行了比较。结果:2016-2021年间,我科登记了46例NIFTP病例,因此在257例PTC中,NIFTP的总发病率为17.9% [CI(95%):7.6-32.5]。当我们比较两个研究期间(2016-2018 年与 2019-2021 年)的 NIFTP 发病率时,我们的数据显示 NIFTP 的总体发病率从 21.4 % [CI (95%): -14.5-60.1]下降到第二个评估期间的 15 % [CI (95%): -8.2-43](P=0.034)。结论2016-2021年间,我院各科室的NIFTP总体发病率较低。此外,在诊断标准修订后,NIFTP 的发病率在 2018 年后有所下降。我们的研究结果突出表明,在诊断NIFTP时需要应用非常严格的形态学标准,以避免误诊和/或过度治疗一种行为不活跃的肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in Mureș County, Romania: Incidence and impact of reclassification over a six-year period (2016-2021)
Abstract Objective: In 2016 a group of expert endocrine pathologists proposed a new terminology, NIFTP (Non-invasive follicular thyroid neoplasm with papillary-like nuclear features) for a histological subtype of thyroid carcinoma (encapsulated follicular variant of papillary thyroid carcinoma, non-invasive type). In this study, we aimed to assess on a retrospective basis the epidemiological trend and overall incidence of NIFTP in Mureș county, Romania, over a six-year period (2016-2021). Methods: All NIFTPs registered between 2016-2021 in Târgu-Mureș Pathology Departments were reevaluated. NIFTP’s incidence was calculated by dividing the number of NIFTPs with the number of papillary thyroid carcinomas (PTCs). Further on, we compared NIFTP’s incidence between 2016-2018 with NIFTP’s incidence between 2019-2021, as the diagnostic criteria of NIFTP were revised in 2018. Results: Forty-six cases of NIFTP were registered in our departments between 2016-2021, resulting in an overall NIFTP incidence of 17.9 % [CI (95%): 7.6-32.5] among the 257 PTCs. When we compared the NIFTP’ incidence between the two study periods (2016-2018 versus 2019-2021), our data revealed that the NIFTP’s overall incidence has dropped from 21.4 % [CI (95%): −14.5-60.1] to 15% [CI (95%): −8.2-43] in the second evaluated period (p=0.034). Conclusion: The overall NIFTP incidence was low in our departments between 2016-2021. Moreover, NIFTP’s incidence decreased after 2018, following revision of the diagnostic criteria. Our results highlight that very stringent morphologic criteria need to be apply when making a diagnosis of NIFTP, in order to avoid a misdiagnosis and/or an overtreatment of a tumor with indolent behavior.
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来源期刊
Acta Marisiensis - Seria Medica
Acta Marisiensis - Seria Medica Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.40
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24 weeks
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