肌肉疏松性肥胖症儿童的身体成分和代谢状况

Pediatria. Journal named after G.N. Speransky Pub Date : 2023-12-15 DOI:10.24110/0031-403x-2023-102-6-74-80

P. Okorokov, O. Vasyukova, M.P. Koltakova, E. Nagaeva

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引用次数: 0

摘要

肥胖症（Sarcopenic obesity，SO）的特点是瘦体重减少，脂肪组织增加，与成人的各种代谢紊乱有关。身体成分对肥胖儿童代谢状况的影响至今仍不清楚。研究目的是评估肌肉疏松性肥胖儿童的身体成分和代谢状况。研究方法：2020 年 2 月至 2022 年 7 月进行了一项横断面单中心研究，纳入了 116 名单纯性肥胖（SDS BMI 2.5 [2.2;2.7] ）儿童（55 名男孩，61 名女孩），年龄为 7 至 17 岁（平均年龄为 14.2 [12.3;15.5] 岁），根据是否存在肌肉疏松性肥胖分为两组。肌肉疏松性肥胖组（"SO+"）包括 56 名单纯性肥胖（SDS BMI 2.5 [2.2; 2.6]）的儿童（19 名男孩，37 名女孩）。对照组（"SO-"）包括 60 名患有体质性肥胖（SDS BMI 2.5 [2.2; 2.7]）但无肌肉疏松症的儿童（36 名男孩，24 名女孩）。结果：患有肌肉疏松性肥胖症的儿童的特点是脂肪组织增加（39.1% [36.4; 41.9] vs 30.6% [27.6; 32.4]; p<0.0001），瘦体重减少（55.6 [44.8; 63.7] vs 45.6 [39.5; 49.7] kg; p<0.0001）和骨骼肌质量减少（25.0 [19.2; 28.2] vs 19.4 [16.3; 22.4] kg; p<0.0001）--所有这些都与 "SO-"组相比。在两组中，发现糖耐量受损（p=0.672）、胰岛素抵抗（p=0.871）和非酒精性脂肪肝（p=0.657）的频率差异无统计学意义。结论：儿童肌肉疏松性肥胖的特点是瘦体重和骨骼肌质量减少，并不伴有代谢特征的变化。因此很难对这类儿童患者的代谢风险进行分层。

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Body composition and metabolic status in children with sarcopenic obesity

Sarcopenic obesity (SO) is characterized by a decrease of lean mass and increase of adipose tissue and is associated with various metabolic disorders in adults. The influence of the body composition on the metabolic profile in obese children remains unclear as yet. The purpose of the research was to assess body composition and metabolic profile in children with sarcopenic obesity Methods used: cross-sectional, single-center study was conducted in Feb. 2020-Jul. 2022 which included 116 children (55 boys, 61 girls) with simple obesity (SDS BMI 2.5 [2.2;2.7]) aged 7 to 17 y/o (average age 14.2 [12.3;15.5] y/o) divided into two groups depending on the presence of sarcopenic obesity. The group with sarcopenic obesity ("SO+") included 56 children (19 boys, 37 girls) with simple obesity (SDS BMI 2.5 [2.2; 2.6]). The control group ("SO-") consisted of 60 children (36 boys, 24 girls) with constitutionally exogenous obesity (SDS BMI 2.5 [2.2; 2.7]) without sarcopenia. Results: children with sarcopenic obesity were characterized by an increase in adipose tissue (39.1% [36.4; 41.9] vs 30.6% [27.6; 32.4]; p<0.0001), decrease in lean mass (55.6 [44.8; 63.7] vs 45.6 [39.5; 49.7] kg; p<0.0001) and skeletal muscle mass decrease (25.0 [19.2; 28.2] vs 19.4 [16.3; 22.4] kg; p<0.0001) - all compared to the "SO-" group. There were no statistically significant differences in the frequency of detection of impaired glucose tolerance (p=0.672), insulin resistance (p=0.871) and non-alcoholic fatty liver disease (p=0.657) in both groups. Conclusion: sarcopenic obesity in children is characterized by a reduction of lean mass and skeletal muscle mass and is not accompanied by changes in the metabolic profile. It makes difficult to stratify metabolic risks in this group of pediatric patients.

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Pediatria. Journal named after G.N. Speransky

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