Altric-Extra 药物在实验动物中的亚慢性口服毒性研究

V. V. Golovin, S. V. Abramov, A. V. Balyshev, E. V. Lagereva
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引用次数: 0

摘要

该研究的目的是确定在对实验室白种大鼠反复胃内注射兽用 Altric-Extra 时的主要毒理学参数。本研究采用白色近交系大鼠作为试验系统。实验采用了临床、毒理学、生物化学和形态学研究方法。325毫克/千克和650毫克/千克的Altric-Extra剂量对实验动物具有毒性。每天按上述剂量对大鼠进行胃内给药时,该药物会对造血器官、排泄系统和消化系统的功能状态产生负面影响。该药物的主要靶器官是胸腺。从给药 10 天后的尸检、一般血液分析和血液生化检验可以看出,上述器官和系统的功能障碍是不可逆的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of subchronic oral toxicity of Altric-Extra drug in laboratory animals
The purpose of the research is to determine main toxicological parameters in repeated intragastric administration of Altric-Extra for veterinary use to laboratory outbred rats.Materials and methods. White outbred rats were used as a test system in the study. The experiment used clinical, toxicological, biochemical and morphological research methods.Results and discussion. Altric-Extra doses of 325 and 650 mg/kg were toxic for the laboratory animals. When administered daily intragastrically to the rats in the above doses, the drug had a negative effect on the functional status of the hemopoietic organs, and excretory and digestive systems. The main target organ for this drug is the thymus. Functional disorders in the above organs and systems are irreversible as evidenced by the post-mortem examination, general blood analysis, and biochemical blood test obtained 10 days after the drug administration was completed.
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