亚临床甲状腺功能减退症与心脏功能性血液动力学

Raisa A. Aringazina, Nurgul Abenova, Sajad Ahmad Bhat
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摘要

亚临床甲状腺功能亢进(SHyper)是指实验室促甲状腺激素水平下降,而外周甲状腺激素水平在参考区间内,被认为是一种病症,尤其是对年轻女性心脏血液动力学的影响。为了确定亚临床甲状腺功能障碍对年轻女性血液动力学的影响,临床观察包括两组女性:(1) 主组由 30 名亚临床甲状腺功能亢进症患者组成,在西哈萨克斯坦马拉特-奥斯帕诺夫医科大学(哈萨克斯坦,阿克托别)家庭医学诊所接受检查;(2) 对照组由 30 名身体健康的女性组成。两组年龄相当(30-42 岁),平均年龄为 36.2±7.0 岁。测量血压(BP),计算心率(HR),并测定甲状腺激素。受检患者未发现病理临床症状;实验室检查结果显示,主要组患者的促甲状腺激素(TSH)下降至 2.与对照组的 3.65±1.3 mIU/L 相比,主要组患者的促甲状腺激素(TSH)下降至 2.48±0.23 mIU/L,血压 SBP/DBP 在 1 分钟内从 122.34±2.7/78.3±2.7 升至 127.8±3.1/83.2±2.1 mmHg,心率从 77.7±1.9 升至 82.2±2.6。TSH -0.236 mIU/L 和 HP +20.3 在 1 分钟内有明显的交互作用(r2 =0.482),这可能是心率增加超过参考值(每分钟 60-80)的预测因素,而心率增加被认为是血压增加的预测因素。亚临床甲状腺功能亢进可能会导致实验室 TSH 显著下降,但没有明显的血压升高临床症状。总之,目前的观察经验表明,促甲状腺激素实验室值的小幅下降可能会影响血压和心率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Subclinical Hypothyroidism and Functional Hemodynamics of the Heart
Subclinical hyperthyroidism (SHyper), a laboratory decrease in thyroid-stimulating hormone levels with peripheral thyroid hormone levels within the reference interval, is considered a medical condition, especially its impact on cardiac hemodynamics among young women. To determine the effects of subclinical thyroid dysfunction on hemodynamics in young women. clinical observation included two groups of women: (1) the main group consisted of 30 patients with subclinical hyperthyroidism, which was examined at the Family Medicine Clinic of the West Kazakhstan Marat Ospanov Medical University (Aktobe, Kazakhstan) and (2) the control group consisted of 30 practically healthy women. The groups were comparable in age (30–42), mean age 36.2±7.0 years. Blood pressure (BP) was measured, heart rate (HR) was counted, and thyroid hormones were determined. in the examined patients, clinical symptoms of pathology were not observed; laboratory tests determined a decrease in thyroid-stimulating hormone (TSH) in the main group of patients to 2.48±0.23 mIU/L in comparison with the control group 3.65±1.3 mIU/L, which was significant (p0.05) increase in blood pressure SBP/DBP from 122.34±2.7/78.3±2.7 to 127.8±3.1/83.2±2.1 mmHg and HR from 77.7±1.9 to 82.2±2.6 in 1 minute. A significant (r2 =0.482) interaction was determined between TSH -0.236 mIU/L and HP +20.3 in 1 minute, this could be a predictor of an increase in heart rate greater than the reference value (60–80 per minute), and an increased heart rate is considered a predictor of an increase in blood pressure. Subclinical hyperthyroidism may produce a significant laboratory decrease in TSH, without significant clinical symptoms of increased blood pressure. In conclusion, current observational experience suggests that small decreases in laboratory values of thyroid-stimulating hormone may affect blood pressure and heart rate.
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