利用海藻的力量:发掘海洋藻类在药物发现中的潜力

Leonel Pereira, A. Valado
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引用次数: 0

摘要

海藻(又称海洋藻类)作为生物活性化合物的重要来源,在药物发现中具有潜在的应用前景,因而备受关注。这篇综述探讨了基于海藻的药物发现这一新兴领域,并重点介绍了在海藻中发现的各种生物活性化合物,包括多糖、叶绿素、色素和肽。这些化合物具有多种药理活性,如抗氧化、抗炎、抗菌、抗病毒和抗癌作用。海藻在癌症研究领域显示出特别的前景,其中某些种类显示出强大的抗肿瘤特性。此外,海藻的抗炎、抗菌和神经保护潜力也引起了科学界对治疗慢性疾病和神经退行性疾病的兴趣。然而,与化合物鉴定、提取方法、海藻栽培的可扩展性以及对作用机制的理解有关的挑战仍有待解决。随着研究人员采用先进技术并深入研究海藻的化学成分,这些海洋生物在药物发现方面尚未开发的潜力有待进一步发掘,并为未来的治疗进步带来巨大希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery
Seaweeds, also known as marine algae, have gained attention as a promising source of bioactive compounds with potential applications in drug discovery. This review explores the emerging field of seaweed-based drug discovery and highlights the diverse range of bioactive compounds found in seaweeds, including polysaccharides, phlorotannins, pigments, and peptides. These compounds exhibit various pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, antiviral, and anticancer effects. Seaweeds have demonstrated particular promise in the areas of cancer research, with certain species showing potent antitumor properties. Additionally, their anti-inflammatory, antimicrobial, and neuroprotective potential has captured scientific interest in the treatment of chronic diseases and neurodegenerative disorders. However, challenges related to compound identification, extraction methods, scalability of seaweed cultivation, and understanding the mechanisms of action still need to be addressed. As researchers employ advanced technologies and dive deeper into the chemical composition of seaweeds, the untapped potential of these marine organisms in drug discovery awaits further exploration and holds significant promise for future therapeutic advancements.
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