来自链霉菌 MA37 变异株的新型抗菌药 Accramycins

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-12-28 DOI:10.3390/m1754

Aziz Alabed, K. Kyeremeh, Hai Deng

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引用次数: 0

摘要

我们一直希望从链霉菌 MA37 变异株 ΔaccJ 中分离出更多具有生物活性的化合物，现已成功鉴定出三种新的安克拉霉素衍生物。通过高分辨率质谱分析以及一维和二维核磁共振，确定了阿克拉霉素 L-N （1-3）的结构。对阿克拉霉素 L-N 针对金黄色葡萄球菌、肺炎克雷伯菌和泄殖腔肠杆菌的抗菌评估显示，其最低抑菌浓度 (MIC) 值介于 0.77 至 13.02 µg/mL 之间。阿克拉霉素 L 对金黄色葡萄球菌的活性最强。此外，阿克拉霉素 L-N (1-3) 对肺炎双球菌也有显著的活性，其 MIC 值分别为 0.81、0.77 和 0.79 µg/mL。

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New Antimicrobial Accramycins from Streptomyces sp. MA37 Variant

In our continued desire to isolate more bioactive compounds from the Streptomyces sp. MA37 variant, ΔaccJ, three new accramycin derivatives have been successfully characterised. The structures of accramycin L-N (1–3) were established by high-resolution mass spectrometry and 1D and 2D nuclear magnetic resonance. The antimicrobial evaluation of accramycin L-N against Staphylococcus aureus, Klebsiella pneumoniae, and Enterobacter cloacae showed minimum inhibitory concentration (MIC) values ranging from 0.77 to 13.02 µg/mL. Accramycin L exhibited the most significant activity against S. aureus. In addition, accramycin L-N (1–3) displayed significant activity against K. pneumoniae at the MIC values of 0.81, 0.77, and 0.79 µg/mL, respectively.

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)