不同阶段宫颈癌患者的血细胞分析图谱和血浆中某些细胞因子的水平

M. Jimoh, Abdulfattah Adekunle Onifade, F. Abbiyesuku, V. F. Edem, S. Rahamon, O. Arinola
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引用次数: 0

摘要

导言和目的。有报告显示,宫颈癌患者的血液和炎症过程发生了改变。然而,有关尼日利亚宫颈癌患者在疾病不同阶段的变化模式的信息却十分匮乏。因此,本研究测定了处于不同阶段的尼日利亚宫颈癌患者的血液细胞学特征以及血浆中白细胞介素-6(IL-6)和IL-12的水平。材料和方法本研究招募了 89 名成人,包括 49 名宫颈癌患者和 40 名表面健康的对照组。使用自动血液分析仪测定血细胞分析图,同时使用酶联免疫吸附法测定血浆中白细胞介素-6(IL-6)和IL-12的水平。结果在宫颈癌患者中,分别有 6.12%、24.49%、53.06% 和 16.33% 的患者处于 I、II、III 和 IV 期。与 I、II 和 III 期患者相比,IV 期患者的血浆 IL-6 平均水平明显较高。不同癌症分期患者的平均血浆 IL-12 水平和血细胞分析图无明显差异。宫颈癌患者的血浆 IL-6 与淋巴细胞计数和癌症分期呈显著正相关,但与充盈细胞体积(PCV)、血红蛋白和白细胞总数(WBC)呈显著负相关。结论白细胞介素 6 似乎在宫颈癌的发展过程中起着重要作用,并可能参与宫颈癌相关的血细胞计数改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Haemocytometric profile and plasma levels of selected cytokines in patients at various stages of cervical cancer
Introduction and aim. Reports have shown that there is alteration in haematological and inflammatory processes in patients with cervical cancer. However, there is the dearth of information on the pattern of alteration in Nigerian patients with cervical cancer at various stages of the disease. Therefore, haemocytometric profile and plasma levels of interleukin-6 (IL-6) and IL-12 were determined in Nigerian patients with cervical cancer at various stages of the disease. Material and methods. Eighty-nine adults consisting of 49 patients with cervical cancer and 40 apparently healthy controls were enrolled into this study. Haemocytometric profile was determined using automated haematology analyzer while the plasma levels of interleukin-6 (IL-6) and IL-12 were determined using ELISA. Results. Of the participants with cervical cancer, 6.12%, 24.49%, 53.06% and 16.33% were in stages I, II, III and IV respectively. The mean plasma IL-6 level was significantly higher in patients at stage IV of the cancer compared with those in stages I, II and III. No significant differences were observed in the mean plasma IL-12 level, and the haemocytometric profile when patients in different stages of the cancer were compared with one another. Plasma IL-6 had significant positive correlation with the lymphocytes count and cancer stage but had significant negative correlation with packed cell volume (PCV), haemoglobin and total white blood cells count (WBC) in patients with cervical cancer. Conclusion. Interleukin-6 appears to play an important role in the progression of cervical cancer and could be involved in cervical cancer-associated alteration in haemocytometric profile.
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