{"title":"2,4,6- 三取代 1,3,5- 三嗪衍生物的合成、表征和生物评估","authors":"V. P. Gilava, P. K. Patel","doi":"10.55218/jasr.2023141102","DOIUrl":null,"url":null,"abstract":"A new series of 2,4,6-trisubstituted 1,3,5-triazine derivatives were synthesized from 2,4,6-trichloro-1,3,5-triazine(Cyanuric Chloride) and 4-(4-aminophenyl)morpholin-3-one via regioselective reaction followed by reflux with substituted aryl amine in the presence of catalytic amount of triethyl amine. All the synthesized compounds were characterized by IR, 1HNMR, Mass and Elemental Analysis. The newly synthesized compounds were also screened for their in vitro antimicrobial activity against standard drugs and some of them found to be remarkably active.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":" 18","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SYNTHESIS, CHARACTERIZATION AND BILOGICAL EVALUATION OF 2,4,6- TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES\",\"authors\":\"V. P. Gilava, P. K. Patel\",\"doi\":\"10.55218/jasr.2023141102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A new series of 2,4,6-trisubstituted 1,3,5-triazine derivatives were synthesized from 2,4,6-trichloro-1,3,5-triazine(Cyanuric Chloride) and 4-(4-aminophenyl)morpholin-3-one via regioselective reaction followed by reflux with substituted aryl amine in the presence of catalytic amount of triethyl amine. All the synthesized compounds were characterized by IR, 1HNMR, Mass and Elemental Analysis. The newly synthesized compounds were also screened for their in vitro antimicrobial activity against standard drugs and some of them found to be remarkably active.\",\"PeriodicalId\":14906,\"journal\":{\"name\":\"Journal of Advanced Scientific Research\",\"volume\":\" 18\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Advanced Scientific Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55218/jasr.2023141102\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Scientific Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55218/jasr.2023141102","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SYNTHESIS, CHARACTERIZATION AND BILOGICAL EVALUATION OF 2,4,6- TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES
A new series of 2,4,6-trisubstituted 1,3,5-triazine derivatives were synthesized from 2,4,6-trichloro-1,3,5-triazine(Cyanuric Chloride) and 4-(4-aminophenyl)morpholin-3-one via regioselective reaction followed by reflux with substituted aryl amine in the presence of catalytic amount of triethyl amine. All the synthesized compounds were characterized by IR, 1HNMR, Mass and Elemental Analysis. The newly synthesized compounds were also screened for their in vitro antimicrobial activity against standard drugs and some of them found to be remarkably active.
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