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引用次数: 0
摘要
受损关节的持续炎症会导致滑膜微环境的代谢失调,引起类风湿性关节炎(RA)细胞活性的致病性改变。最近,代谢物和代谢物传感 G 蛋白偶联受体(GPCR)在 RA 相关炎症免疫反应(IIR)中的作用成为研究关注的焦点。这些 GPCR 通过调节免疫细胞的活化、迁移和炎症反应,参与了 RA 的进展。在此,我们讨论了最近有证据表明代谢失调与 RA 发病机制有关,重点是 RA 相关 IIR 与源自滑膜关节和肠道的 GPCR 信号之间的联系。此外,我们还讨论了针对代谢感应 GPCRs 治疗的未来方向,强调了识别内源性配体和研究各种相关转导机制的重要性。
Persistent inflammation in damaged joints results in metabolic dysregulation of the synovial microenvironment, causing pathogenic alteration of cell activity in rheumatoid arthritis (RA). Recently, the role of metabolite and metabolite-sensing G protein-coupled receptors (GPCRs) in the RA-related inflammatory immune response (IIR) has become a focus of research attention. These GPCRs participate in the progression of RA by modulating immune cell activation, migration, and inflammatory responses. Here, we discuss recent evidence implicating metabolic dysregulation in RA pathogenesis, focusing on the connection between RA-related IIR and GPCR signals originating from the synovial joint and gut. Furthermore, we discuss future directions for targeting metabolite-sensing GPCRs for therapeutic benefit, emphasizing the importance of identifying endogenous ligands and investigating the various transduction mechanisms involved.
期刊介绍:
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.