含苄基醚尾的新型呫吨-1,8-二酮衍生物作为强效细胞毒剂：设计、合成、体外和硅学研究

IF 2.8 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemistry Pub Date : 2024-01-05 DOI:10.1155/2024/6612503

Ahmad Ebadi, Aref Karimi, Asrin Bahmani, Zahra Najafi, Gholamabbas Chehardoli

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引用次数: 0

摘要

研究人员合成了十七种新的呫吨-1,8-二酮衍生物，并将其作为抗肺癌细胞系（A549）的细胞毒剂进行了评估。与顺铂相比，化合物 9-(4-(苄氧基)苯基)-3,4,5,6,7,9-六氢-1H-呫吨-1,8(2H)-二酮（4a）显示出良好的细胞毒性效果（34.59 μM）。Docking 结果表明，4a 能与 DNA 发生插层作用。化合物 4a 的计算配体效率高于达诺霉素。根据这些结果，可以认为化合物 4a 是一种合适的 DNA 结合剂。

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Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies

Seventeen new xanthene-1,8-dione derivatives were synthesized and evaluated as cytotoxic agents against the lung carcinoma cell line (A549). Compound 9-(4-(benzyloxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (4a) showed good cytotoxic effects (34.59 μM) in comparison to cis-platin. Docking results showed 4a could interact with DNA as intercalation. Calculated ligand efficiency of compound 4a was more than daunomycin. Based on the results, it can be concluded that compound 4a is a suitable DNA binding agent.

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来源期刊

Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

5.90

自引率

3.30%

发文量

345

审稿时长

16 weeks

期刊介绍： Journal of Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry.