果糖诱导的 FGF21 分泌不会激活日本年轻男性的棕色脂肪组织：随机交叉和随机对照试验

IF 3.1 4区医学 Q1 Social Sciences

Journal of Physiological Anthropology Pub Date : 2024-01-04 DOI:10.1186/s40101-023-00353-0

Haruki Kataoka, Shinsuke Nirengi, Yuka Matsui, Hirokazu Taniguchi

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引用次数: 0

摘要

人体棕色脂肪组织（BAT）的活性与较低的体脂率和良好的糖代谢有关。以前的研究报告称，口服果糖负荷可诱导餐后成纤维细胞生长因子 21（FGF21）的分泌。FGF21 是一种已知的脂肪组织产热诱导因子；然而，饮食诱导的 FGF21 分泌对 BAT 产热的影响仍有待阐明。研究人员采用随机交叉试验和为期两周的随机对照试验（RCT），分别研究了单次摄入果糖和每天摄入果糖对BAT活动的影响。在交叉试验中，15 名年轻男性饮用了单剂量的果糖溶液或水，然后在随后的一天饮用了另一种果糖溶液或水。随机对照试验招募了 22 名年轻男性，参与者被分配到每天摄入果糖的一组和每天摄入水的一组，为期 2 周。采用冷暴露热成像技术分析了BAT活性。血浆 FGF21 水平通过酶联免疫吸附试验测定。在交叉单负荷试验中，口服果糖后 2 小时，血浆中的 FGF21 水平显著升高（p < 0.01）；然而，果糖负荷组和饮水组的 BAT 活性没有显著差异。为期两周的研究表明，与饮水相比，每天摄入果糖并不会明显增加血浆中的 FGF21 水平和 BAT 活性。相关性分析表明，基线和最终测量结果显示，BAT活性与RCT密切正相关（r = 0.869，p < 0.001）。在为期 2 周的干预期间，BAT 活性的变化与血浆葡萄糖水平的变化呈显著负相关（r = - 0.497，p = 0.022）。口服果糖可诱导循环中的 FGF21 水平暂时升高，但这并不能激活健康年轻男性体内的 BAT 产热。要阐明内源性 FGF21 对生理功能的影响，还需要进一步的研究。本研究已在日本大学医院医学信息网注册（编号000051761，注册日期2023年8月1日，回顾性注册，https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000052680 ）。

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Fructose-induced FGF21 secretion does not activate brown adipose tissue in Japanese young men: randomized cross-over and randomized controlled trials

Human brown adipose tissue (BAT) activity is associated with lower body fatness and favorable glucose metabolism. Previous studies reported that oral fructose loading induces postprandial fibroblast growth factor 21 (FGF21) secretion. FGF21 is a known inducer of adipose tissue thermogenesis; however, the effects of diet-induced FGF21 secretion on BAT thermogenesis remain to be elucidated. The effects of both single load and daily consumption of fructose on BAT activity were examined using a randomized cross-over trial and a 2-week randomized controlled trial (RCT), respectively. In the cross-over trial, 15 young men consumed a single dose of fructose solution or water and then consumed the other on a subsequent day. The RCT enrolled 22 young men, and the participants were allocated to a group that consumed fructose and a group that consumed water daily for 2 weeks. BAT activity was analyzed using thermography with cold exposure. Plasma FGF21 level was determined by enzyme-linked immunosorbent assay. In the cross-over single-load trial, plasma FGF21 levels were significantly increased at 2 h after oral fructose load (p < 0.01); however, there was no significant difference in BAT activity between the fructose load and drinking water. The 2-week RCT revealed that both plasma FGF21 levels and BAT activity were not significantly increased by daily fructose consumption compared to water. Correlation analyses revealed that BAT activity at the baseline and the final measurements were strongly and positively associated with the RCT (r = 0.869, p < 0.001). Changes in BAT activity were significantly and negatively correlated with changes in plasma glucose levels during the 2-week intervention (r = − 0.497, p = 0.022). Oral fructose load induces a temporary increase in circulating FGF21 levels; however, this does not activate BAT thermogenesis in healthy young men. Further studies are needed to elucidate the effect of endogenous FGF21 on physiological function. This study is registered with the University Hospital Medical Information Network in Japan (number 000051761, registered 1 August 2023, retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000052680 ).

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来源期刊

Journal of Physiological Anthropology Social Sciences-Human Factors and Ergonomics

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Physiological Anthropology (JPA) is an open access, peer-reviewed journal that publishes research on the physiological functions of modern mankind, with an emphasis on the physical and bio-cultural effects on human adaptability to the current environment. The objective of JPA is to evaluate physiological adaptations to modern living environments, and to publish research from different scientific fields concerned with environmental impact on human life. Topic areas include, but are not limited to: environmental physiology bio-cultural environment living environment epigenetic adaptation development and growth age and sex differences nutrition and morphology physical fitness and health Journal of Physiological Anthropology is the official journal of the Japan Society of Physiological Anthropology.