Serena Low , Tze Pin Ng , Kiat Sern Goh , Angela Moh , Jonathon Khoo , Keven Ang , Philip Yap , Chin Yee Cheong , Wern Ee Tang , Ziliang Lim , Tavintharan Subramaniam , Chee Fang Sum , Su Chi Lim
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SVR was assessed based on bioelectrical impedance measurements of muscle mass and visceral fat area (VFA). Cognitive function was assessed using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Linear regression was used to examine the association between SVR in quartiles and RBANS score, adjusting for demographics, education, presence of depressive symptoms, clinical covariates and medications.</p></div><div><h3>Results</h3><p>The lower SVR quartiles were negatively associated with RBANS total score in the unadjusted analysis. The corresponding coefficients for Quartiles 1 and 2 SVR were −3.79 (95 % CI −5.39 to −2.19; p < 0.001) and −1.47 (95 % CI −2.86 to −0.07; p = 0.039) in fully adjusted analysis. The negative association between Quartile 1 SVR and RBANS score was evident in immediate memory, delayed memory, visuo-spatial construction, language and attention domains. Muscle mass and VFA alone had weaker associations with RBANS scores.</p></div><div><h3>Conclusion</h3><p>Our study demonstrated, for the first time, an independent association between reduced SVR and lower cognitive function. This is evident in global and multiple cognitive domains. The synergistic effects of reduced muscle mass and visceral obesity may be more pronounced than their independent effects on cognitive function.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reduced skeletal muscle mass to visceral fat area ratio is independently associated with reduced cognitive function in type 2 diabetes mellitus\",\"authors\":\"Serena Low , Tze Pin Ng , Kiat Sern Goh , Angela Moh , Jonathon Khoo , Keven Ang , Philip Yap , Chin Yee Cheong , Wern Ee Tang , Ziliang Lim , Tavintharan Subramaniam , Chee Fang Sum , Su Chi Lim\",\"doi\":\"10.1016/j.jdiacomp.2023.108672\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>Skeletal muscle<span><span><span> mass to visceral fat area ratio (SVR) has been recognised as an index of </span>sarcopenic obesity<span><span>. 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引用次数: 0
摘要
目的骨骼肌质量与内脏脂肪面积比(SVR)被认为是肌肉疏松性肥胖的指标。SVR 与 2 型糖尿病(T2DM)、代谢综合征和动脉僵化有关,而这些都是已知的认知功能障碍的风险因素。我们的目的是研究 SVR 与 T2DM 患者认知功能之间的关系。方法这是一项横断面研究,研究对象为 1326 名 T2DM 患者,平均年龄为 61.3 ± 8.0 岁。SVR 根据肌肉质量和内脏脂肪面积(VFA)的生物电阻抗测量结果进行评估。认知功能使用神经心理状态评估可重复性电池(RBANS)进行评估。在对人口统计学、教育程度、是否存在抑郁症状、临床协变量和药物进行调整后,采用线性回归法检测 SVR 四分位数与 RBANS 分数之间的关系。在完全调整分析中,SVR 四分位数 1 和 2 的相应系数分别为 -3.79 (95 % CI -5.39 to -2.19; p < 0.001) 和 -1.47 (95 % CI -2.86 to -0.07; p = 0.039)。第 1 季度 SVR 与 RBANS 评分之间的负相关在即时记忆、延迟记忆、视觉空间结构、语言和注意力领域都很明显。我们的研究首次证明了 SVR 降低与认知功能降低之间的独立联系。我们的研究首次证明了 SVR 降低与认知功能降低之间的独立关联。肌肉量减少和内脏肥胖的协同作用可能比它们对认知功能的独立影响更明显。
Reduced skeletal muscle mass to visceral fat area ratio is independently associated with reduced cognitive function in type 2 diabetes mellitus
Aim
Skeletal muscle mass to visceral fat area ratio (SVR) has been recognised as an index of sarcopenic obesity. SVR is associated with type 2 diabetes mellitus (T2DM), metabolic syndrome and arterial stiffness which are known risk factors for cognitive dysfunction. We aimed to investigate association between SVR and cognitive function in patients with T2DM.
Methods
This was a cross-sectional study of 1326 patients with T2DM and mean age 61.3 ± 8.0 years. SVR was assessed based on bioelectrical impedance measurements of muscle mass and visceral fat area (VFA). Cognitive function was assessed using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Linear regression was used to examine the association between SVR in quartiles and RBANS score, adjusting for demographics, education, presence of depressive symptoms, clinical covariates and medications.
Results
The lower SVR quartiles were negatively associated with RBANS total score in the unadjusted analysis. The corresponding coefficients for Quartiles 1 and 2 SVR were −3.79 (95 % CI −5.39 to −2.19; p < 0.001) and −1.47 (95 % CI −2.86 to −0.07; p = 0.039) in fully adjusted analysis. The negative association between Quartile 1 SVR and RBANS score was evident in immediate memory, delayed memory, visuo-spatial construction, language and attention domains. Muscle mass and VFA alone had weaker associations with RBANS scores.
Conclusion
Our study demonstrated, for the first time, an independent association between reduced SVR and lower cognitive function. This is evident in global and multiple cognitive domains. The synergistic effects of reduced muscle mass and visceral obesity may be more pronounced than their independent effects on cognitive function.
期刊介绍:
Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis.
The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications.
Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.