调节性 B 细胞在免疫调节和儿童过敏性哮喘中的作用。

IF 2.4 Q1 PEDIATRICS
Caroline Vanessa Kliem, Bianca Schaub
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引用次数: 0

摘要

背景:作为儿童时期最常见的慢性疾病,哮喘是一个全球性的重大公共卫生问题,发病率不断上升。由于过敏性哮喘目前尚无根治方法,因此必须更好地了解其分子机制:通过在接触过敏原时产生 IgE 抗体,B 细胞在过敏性哮喘中起着关键作用。此外,据报道,在小鼠和人类中,分泌 IL-10 的 B 细胞亚群,即调节性 B 细胞(Bregs)在过敏性哮喘中发挥作用。在人类中,在处于不同成熟和分化阶段的 B 细胞中发现了几种具有不同表型和功能特性的 Breg 亚群,它们通过表达几种抑制分子来发挥抗炎功能。新的研究重点是 Bregs 在过敏性哮喘中的作用以及它们在未来诊断和预防策略中的作用:有关人类 Bregs 在过敏性哮喘中确切功能的知识仍然非常有限。本综述旨在总结目前有关 Bregs 的知识。我们讨论了不同的人类 Breg 亚群、Breg 诱导的几种方式及其发挥免疫调节功能的机制,以及它们在(儿童)过敏性哮喘中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of regulatory B cells in immune regulation and childhood allergic asthma.

Background: As the most common chronic disease in childhood, asthma displays a major public health problem worldwide with the incidence of those affected rising. As there is currently no cure for allergic asthma, it is mandatory to get a better understanding of the underlying molecular mechanism.

Main body: By producing IgE antibodies upon allergen contact, B cells play a pivotal role in allergic asthma. Besides that, IL-10-secreting B cell subsets, namely regulatory B cells (Bregs), are reported in mice and humans to play a role in allergic asthma. In humans, several Breg subsets with distinct phenotypic and functional properties are identified among B cells at different maturational and differentiation stages that exert anti-inflammatory functions by expressing several suppressor molecules. Emerging research has focused on the role of Bregs in allergic asthma as well as their role for future diagnostic and preventive strategies.

Conclusion: Knowledge about the exact function of human Bregs in allergic asthma is still very limited. This review aims to summarize the current knowledge on Bregs. We discuss different human Breg subsets, several ways of Breg induction as well as the mechanisms through which they exert immunoregulatory functions, and their role in (childhood) allergic asthma.

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