从果蝇到哺乳动物的细胞竞争与癌症

IF 5.9 2区医学 Q1 ONCOLOGY

Oncogenesis Pub Date : 2024-01-03 DOI:10.1038/s41389-023-00505-y

Bojie Cong, Ross L Cagan

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引用次数: 0

摘要

在人的一生中，体细胞会发生与癌症相关的突变。其中一部分突变会诱发肿瘤的形成，这种现象部分是由突变型细胞克隆和野生型细胞克隆争夺优势地位的相互作用所驱动的；反之，其他突变则对肿瘤的形成起抑制作用。这种 "细胞竞争 "机制可以通过评估克隆群体的相对地位来改变克隆动态，促进 "赢家"，淘汰 "输家"。本综述探讨了细胞竞争在肿瘤发生、肿瘤进展和治疗干预中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cell competition and cancer from Drosophila to mammals.

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Cell competition and cancer from Drosophila to mammals.

Throughout an individual's life, somatic cells acquire cancer-associated mutations. A fraction of these mutations trigger tumour formation, a phenomenon partly driven by the interplay of mutant and wild-type cell clones competing for dominance; conversely, other mutations function against tumour initiation. This mechanism of 'cell competition', can shift clone dynamics by evaluating the relative status of clonal populations, promoting 'winners' and eliminating 'losers'. This review examines the role of cell competition in the context of tumorigenesis, tumour progression and therapeutic intervention.

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来源期刊

Oncogenesis ONCOLOGY-

CiteScore

11.90

自引率

0.00%

发文量

审稿时长

26 weeks

期刊介绍： Oncogenesis is a peer-reviewed open access online journal that publishes full-length papers, reviews, and short communications exploring the molecular basis of cancer and related phenomena. It seeks to promote diverse and integrated areas of molecular biology, cell biology, oncology, and genetics.