瑞舒伐他汀单药和瑞舒伐他汀/依折麦布联合疗法对 2 型糖尿病患者胰岛素敏感性和血管炎症反应的疗效比较。

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2024-01-01 Epub Date: 2024-01-03 DOI:10.4093/dmj.2022.0402
Ji Hye Han, Kyong Hye Joung, Jun Choul Lee, Ok Soon Kim, Sorim Choung, Ji Min Kim, Yea Eun Kang, Hyon-Seung Yi, Ju Hee Lee, Bon Jeong Ku, Hyun Jin Kim
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引用次数: 0

摘要

背景:2型糖尿病(T2DM)会诱发内皮功能障碍和炎症,而内皮功能障碍和炎症是导致动脉粥样硬化和心血管疾病的主要因素。本研究旨在比较罗伐他汀单药治疗和罗伐他汀/依泽替米贝联合治疗对 T2DM 患者血脂状况、胰岛素敏感性和血管炎症反应的影响:将101名患有T2DM和血脂异常的患者随机分为罗伐他汀单药治疗(5毫克/天,47人)或罗伐他汀/依泽替米贝联合治疗(5毫克/10毫克/天,45人),治疗12周。在治疗前和治疗 12 周后测定血清脂质、葡萄糖、胰岛素、可溶性细胞间粘附分子-1(sICAM-1)和过氧化还原酶 4(PRDX4)的水平:结果:联合疗法组的低密度脂蛋白胆固醇(LDL-C)在治疗后比基线降低了 50%以上。两组的血清 sICAM-1 水平均显著升高,但两组间无差异。胰岛素抵抗稳态模型评估(HOMA-IR)和 PRDX4 的明显变化仅在低密度脂蛋白胆固醇(LDL-C)降低 50%或以上的联合治疗组亚组中得到证实。然而,在对糖尿病病程和高血压进行调整后,两组之间的HOMA-IR和PRDX4变化并不显著:结论:虽然罗伐他汀/依泽替米贝联合疗法比罗伐他汀单药疗法有更大的降低低密度脂蛋白胆固醇的作用,但对胰岛素敏感性和血管炎症反应没有额外的影响。关于依折麦布长期治疗对胰岛素敏感性和血管炎症反应的影响,还需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus.

Backgruound: Type 2 diabetes mellitus (T2DM) induces endothelial dysfunction and inflammation, which are the main factors for atherosclerosis and cardiovascular disease. The present study aimed to compare the effects of rosuvastatin monotherapy and rosuvastatin/ezetimibe combination therapy on lipid profile, insulin sensitivity, and vascular inflammatory response in patients with T2DM.

Methods: A total of 101 patients with T2DM and dyslipidemia were randomized to either rosuvastatin monotherapy (5 mg/day, n=47) or rosuvastatin/ezetimibe combination therapy (5 mg/10 mg/day, n=45) and treated for 12 weeks. Serum lipids, glucose, insulin, soluble intercellular adhesion molecule-1 (sICAM-1), and peroxiredoxin 4 (PRDX4) levels were determined before and after 12 weeks of treatment.

Results: The reduction in low density lipoprotein cholesterol (LDL-C) by more than 50% from baseline after treatment was more in the combination therapy group. The serum sICAM-1 levels increased significantly in both groups, but there was no difference between the two groups. The significant changes in homeostasis model assessment of insulin resistance (HOMA-IR) and PRDX4 were confirmed only in the subgroup in which LDL-C was reduced by 50% or more in the combination therapy group. However, after adjusting for diabetes mellitus duration and hypertension, the changes in HOMA-IR and PRDX4 were not significant between the two groups.

Conclusion: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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