Jesus A Mosquera-Sulbaran, Adriana Pedreañez, Yenddy Carrero, Juan Pablo Hernandez-Fonseca
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引用次数: 0
摘要
背景:链球菌后肾小球肾炎(PSGN)是 A 组β-溶血性链球菌感染的后果。在感染过程中,链球菌抗原会引发各种免疫过程,如诱导抗体和免疫复合物。这种免疫系统的激活涉及先天性免疫和获得性免疫。在肾脏水平发生的免疫事件会导致肾脏损伤,引起慢性肾衰竭,同时也会缓解病理过程(在大多数情况下)。血管紧张素 II(Ang II)是一种具有血管舒张和促炎症能力的分子,是各种炎症过程的重要因素。在 PSGN 期间发生的一些事件表明,血管紧张素 II 是一种参与疾病炎症过程的分子:本综述的重点是确定哪些报告事件与 PSGN 中存在的这种激素有关。
Angiotensin II and post-streptococcal glomerulonephritis.
Background: Post-streptococcal glomerulonephritis (PSGN) is a consequence of the infection by group A beta-hemolytic streptococcus. During this infection, various immunological processes generated by streptococcal antigens are triggered, such as the induction of antibodies and immune complexes. This activation of the immune system involves both innate and acquired immunity. The immunological events that occur at the renal level lead to kidney damage with chronic renal failure as well as resolution of the pathological process (in most cases). Angiotensin II (Ang II) is a molecule with vasopressor and pro-inflammatory capacities, being an important factor in various inflammatory processes. During PSGN some events are defined that make Ang II conceivable as a molecule involved in the inflammatory processes during the disease.
Conclusion: This review is focused on defining which reported events would be related to the presence of this hormone in PSGN.
期刊介绍:
Clinical and Experimental Nephrology is a peer-reviewed monthly journal, officially published by the Japanese Society of Nephrology (JSN) to provide an international forum for the discussion of research and issues relating to the study of nephrology. Out of respect for the founders of the JSN, the title of this journal uses the term “nephrology,” a word created and brought into use with the establishment of the JSN (Japanese Journal of Nephrology, Vol. 2, No. 1, 1960). The journal publishes articles on all aspects of nephrology, including basic, experimental, and clinical research, so as to share the latest research findings and ideas not only with members of the JSN, but with all researchers who wish to contribute to a better understanding of recent advances in nephrology. The journal is unique in that it introduces to an international readership original reports from Japan and also the clinical standards discussed and agreed by JSN.