壳聚糖基混合超吸附剂在控制药物输送中的应用。

IF 2.5 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Medha, Sapna Sethi
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引用次数: 0

摘要

本研究以马来酸为交联剂,丙烯酰胺为接枝剂,利用自由基机制制备了壳聚糖-精氨酸混合超吸收剂。该复合水凝胶具有良好的溶胀能力、血液相容性和生物相容性,因此可用作给药装置。X 射线衍射、傅立叶变换红外光谱、X 射线光电子能谱和热分析等表征技术表明,成功合成了具有丰富功能的稳定水凝胶。盐酸二甲双胍被用作治疗糖尿病的模型药物。水凝胶合成后,采用膨胀扩散法进行药物包封。在生理 pH 值下,二甲双胍从载药的水凝胶中释放出来,这突出了药物和水凝胶之间非共价相互作用的作用。二甲双胍从载药水凝胶中的体外释放研究表明,与胃的 pH 值(1.2)相比,二甲双胍在肠道 pH 值(7.4)下的释放曲线更高。布鲁瑙尔-埃美特-泰勒分析显示了水凝胶的表面积、孔径和孔体积对药物释放的影响。与纯壳聚糖水凝胶相比,壳聚糖-精氨酸混合水凝胶的药物释放更持久。对于目前的给药系统来说,溶胀控制释放比 pH 控制释放更为重要。合成的水凝胶可以成功地用作一种潜在的控释给药系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chitosan based hybrid superabsorbent for controlled drug delivery application

In the present study, a hybrid chitosan-alginate superabsorbent is prepared using maleic acid as a cross-linker and acrylamide as a grafting agent using the free radical mechanism. The composite hydrogel shows good swelling capacity along with hemocompatibility and biocompatibility and hence it is utilized as a drug delivery device. The characterization techniques including x-ray diffraction, Fourier transform infrared, x-ray photoelectron spectroscopy, and thermal analysis indicate the successful synthesis of stable hydrogel with rich functionalities. Metformin hydrochloride is used as a model drug which is used to treat diabetes. The drug encapsulation is done using the swelling diffusion method after the synthesis of hydrogel. The release of metformin from the drug-loaded hydrogel at physiological pH highlights the role of non-covalent interactions between the drug and hydrogel. In vitro release studies of Metformin from the drug-loaded hydrogel show higher release profiles at intestinal pH (7.4) compared to stomach pH (1.2). The observed cumulative release is 82.71% at pH 7.4 and 45.67% at pH 1.2 after 10 h. Brunauer–Emmett–Teller analysis reveals the effect of surface area, pore size, and pore volume of hydrogel on the drug release. The drug release from the hybrid chitosan-alginate hydrogel is found to be more sustained in comparison to the pure chitosan hydrogel. For the present drug delivery system, the swelling-controlled release is found to be more dominating than the pH-controlled release. The synthesized hydrogel can be successfully employed as a potential drug delivery system for controlled drug delivery.

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来源期刊
Biotechnology Progress
Biotechnology Progress 工程技术-生物工程与应用微生物
CiteScore
6.50
自引率
3.40%
发文量
83
审稿时长
4 months
期刊介绍: Biotechnology Progress , an official, bimonthly publication of the American Institute of Chemical Engineers and its technological community, the Society for Biological Engineering, features peer-reviewed research articles, reviews, and descriptions of emerging techniques for the development and design of new processes, products, and devices for the biotechnology, biopharmaceutical and bioprocess industries. Widespread interest includes application of biological and engineering principles in fields such as applied cellular physiology and metabolic engineering, biocatalysis and bioreactor design, bioseparations and downstream processing, cell culture and tissue engineering, biosensors and process control, bioinformatics and systems biology, biomaterials and artificial organs, stem cell biology and genetics, and plant biology and food science. Manuscripts concerning the design of related processes, products, or devices are also encouraged. Four types of manuscripts are printed in the Journal: Research Papers, Topical or Review Papers, Letters to the Editor, and R & D Notes.
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