年龄小于或等于 50 岁与大于 50 岁脑肿瘤患者的比较性回顾性生存分析研究。

Asian journal of neurosurgery Pub Date : 2023-12-29 eCollection Date: 2023-12-01 DOI:10.1055/s-0043-1777271
Radha Kesarwani, Astha Singh, Mohammad Aqueel, Virendra Singh, Gyan Prakash
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摘要

导言:大约 2.5% 的癌症死亡病例是由脑肿瘤引起的。尽管有文献对成人脑肿瘤的预后因素进行了研究,但这些研究通常采用西方的人口统计学特征。因此,我们开展了这项回顾性观察研究,以比较印度人口中胶质瘤患者的人口统计学特征和预后,以及组织学诊断与年龄的关系。材料与方法 我们对 76 名接受过手术治疗、放疗和化疗或未接受化疗的胶质瘤患者进行了单中心回顾性观察研究。第一组患者年龄小于或等于 50 岁,第二组患者年龄大于 50 岁。I 组有 28 名患者,II 组有 48 名患者。术后,使用远程钴 60 按常规分次(1.8 Gy/次,5 次/周)进行外照射治疗。III 级和 IV 级胶质瘤患者在放疗期间接受了替莫唑胺口服化疗,剂量为每天 100 毫克。结果 患者确诊时的中位年龄为 45.0 岁。第一组发生血液学毒性的病例多于第二组。共有 55 名患者在 1 年的随访中存活(I 组 11 人,II 组 44 人)。结论 I 级和 II 级胶质瘤主要发生在 50 岁以下的患者中,III 级和 IV 级胶质瘤主要发生在 50 岁以上的患者中。50 岁以上年龄组中男性占多数(68%)。50 岁以下患者的总生存率和无病生存率较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comparative Retrospective Survival Analysis Study of Brain Tumor Patients in Age Less Than or Equal to 50 Years versus More Than 50 Years of Age.

Introduction  Approximately 2.5% of fatalities from cancer are caused by brain tumors. Even though there is literature regarding prognostic factor of adult brain tumor, studies often resort to Western demographics. Hence, we conducted this retrospective observational study to compare the demographic characteristics and prognosis in patients of glial tumors in Indian population with histological diagnosis with respect to age. Materials and Methods  A single-center retrospective observational study with 76 patients of glioma who had been treated with surgery combined with radiotherapy with or without chemotherapy was conducted. Group I patients were aged less than or equal to 50 years and group II more than 50 years of age. There were 28 patients in group I and 48 in group II. Postoperatively, external beam radiation therapy was delivered in a conventional fraction (1.8 Gy/fraction, five fractions/week) using telecobalt 60. Ill patients who presented with grade III and IV gliomas received oral chemotherapy temozolomide at a dose of 100 mg daily during course of radiotherapy. Results  The median age of the patients at the time of diagnosis was 45.0 years. More cases of hematologic toxicity occurred in group I than in group II. Total 55 patients were alive at 1-year follow-up (11 in group I and 44 in group II). Conclusion  Grade I and II gliomas were predominant in less than 50 years of age and grade III and IV were predominant in more than 50 years age. Male preponderance was seen in age group of more than 50 years (68%). Overall survival and disease-free survival were better for patients aged less than 50 years.

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