{"title":"化学感知阵列中的时间逆对称破缺:非对称开关和耗散增强感应","authors":"David Hathcock, Qiwei Yu, Yuhai Tu","doi":"arxiv-2312.17424","DOIUrl":null,"url":null,"abstract":"The Escherichia coli chemoreceptors form an extensive array that achieves\ncooperative and adaptive sensing of extracellular signals. The receptors\ncontrol the activity of histidine kinase CheA, which drives a non-equilibrium\nphosphorylation-dephosphorylation reaction cycle for response regulator CheY.\nRecent single-cell FRET measurements revealed that kinase activity of the array\nspontaneously switches between active and inactive states, with asymmetric\nswitching times that signify time-reversal symmetry breaking in the underlying\ndynamics. Here, we show that the asymmetric switching dynamics can be explained\nby a non-equilibrium lattice model, which considers both the dissipative\nreaction cycles of individual core units and the coupling between neighboring\nunits. The model reveals that large dissipation and near-critical coupling are\nrequired to explain the observed switching dynamics. Microscopically, the\nswitching time asymmetry originates from irreversible transition paths. The\nmodel shows that strong dissipation enables sensitive and rapid signaling\nresponse by relieving the speed-sensitivity trade-off, which can be tested by\nfuture single-cell experiments. Overall, our model provides a general framework\nfor studying biological complexes composed of coupled subunits that are\nindividually driven by dissipative cycles and the rich non-equilibrium physics\nwithin.","PeriodicalId":501325,"journal":{"name":"arXiv - QuanBio - Molecular Networks","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Time-reversal symmetry breaking in the chemosensory array: asymmetric switching and dissipation-enhanced sensing\",\"authors\":\"David Hathcock, Qiwei Yu, Yuhai Tu\",\"doi\":\"arxiv-2312.17424\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The Escherichia coli chemoreceptors form an extensive array that achieves\\ncooperative and adaptive sensing of extracellular signals. The receptors\\ncontrol the activity of histidine kinase CheA, which drives a non-equilibrium\\nphosphorylation-dephosphorylation reaction cycle for response regulator CheY.\\nRecent single-cell FRET measurements revealed that kinase activity of the array\\nspontaneously switches between active and inactive states, with asymmetric\\nswitching times that signify time-reversal symmetry breaking in the underlying\\ndynamics. Here, we show that the asymmetric switching dynamics can be explained\\nby a non-equilibrium lattice model, which considers both the dissipative\\nreaction cycles of individual core units and the coupling between neighboring\\nunits. The model reveals that large dissipation and near-critical coupling are\\nrequired to explain the observed switching dynamics. Microscopically, the\\nswitching time asymmetry originates from irreversible transition paths. The\\nmodel shows that strong dissipation enables sensitive and rapid signaling\\nresponse by relieving the speed-sensitivity trade-off, which can be tested by\\nfuture single-cell experiments. Overall, our model provides a general framework\\nfor studying biological complexes composed of coupled subunits that are\\nindividually driven by dissipative cycles and the rich non-equilibrium physics\\nwithin.\",\"PeriodicalId\":501325,\"journal\":{\"name\":\"arXiv - QuanBio - Molecular Networks\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"arXiv - QuanBio - Molecular Networks\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/arxiv-2312.17424\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Molecular Networks","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2312.17424","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Time-reversal symmetry breaking in the chemosensory array: asymmetric switching and dissipation-enhanced sensing
The Escherichia coli chemoreceptors form an extensive array that achieves
cooperative and adaptive sensing of extracellular signals. The receptors
control the activity of histidine kinase CheA, which drives a non-equilibrium
phosphorylation-dephosphorylation reaction cycle for response regulator CheY.
Recent single-cell FRET measurements revealed that kinase activity of the array
spontaneously switches between active and inactive states, with asymmetric
switching times that signify time-reversal symmetry breaking in the underlying
dynamics. Here, we show that the asymmetric switching dynamics can be explained
by a non-equilibrium lattice model, which considers both the dissipative
reaction cycles of individual core units and the coupling between neighboring
units. The model reveals that large dissipation and near-critical coupling are
required to explain the observed switching dynamics. Microscopically, the
switching time asymmetry originates from irreversible transition paths. The
model shows that strong dissipation enables sensitive and rapid signaling
response by relieving the speed-sensitivity trade-off, which can be tested by
future single-cell experiments. Overall, our model provides a general framework
for studying biological complexes composed of coupled subunits that are
individually driven by dissipative cycles and the rich non-equilibrium physics
within.