前驱阿尔茨海默病中句法-语义界面的解体:无记忆力轻度认知障碍(aMCI)中复杂句子拟合的新证据

IF 1.2 3区 心理学 Q2 LINGUISTICS
Barbara Lust , Suzanne Flynn , Charles Henderson , James Gair , Janet Cohen Sherman
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引用次数: 0

摘要

尽管在阿尔茨海默病(AD)前驱期广泛观察到各种语言障碍,但这些障碍的基本性质及其解释仍然不清楚。因此,临床应用和大脑语言模型都没有得到很好的定义。在本文中,我们报告了两项实验的结果,这两项实验测试了一组患有失忆性轻度认知障碍(aMCI)的人的语言生成能力,并与健康的老年人和健康的年轻人进行了对比。实验采用了以语言学分析为基础的因子设计,测试了两种形式的复杂句子,其中涉及拟声词(代词与前置词之间的关系)。结果表明,患有注意力缺失症的个体会根据句子结构来区分拟人句的形式,其中涉及参照上下文进行构词(拟人核心参照)的句子会出现选择性障碍。我们认为,aMCI患者在保持核心结构知识的同时,也表现出句法-语义整合方面的缺陷,从而将缺陷的根源定位在语言学院的语言-思维界面上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disintegration at the syntax-semantics interface in prodromal Alzheimer's disease: New evidence from complex sentence anaphora in amnestic Mild Cognitive Impairment (aMCI)

Although diverse language deficits have been widely observed in prodromal Alzheimer's disease (AD), the underlying nature of such deficits and their explanation remains opaque. Consequently, both clinical applications and brain-language models are not well-defined. In this paper we report results from two experiments which test language production in a group of individuals with amnestic Mild Cognitive Impairment (aMCI) in contrast to healthy aging and healthy young. The experiments apply factorial designs informed by linguistic analysis to test two forms of complex sentences involving anaphora (relations between pronouns and their antecedents). Results show that aMCI individuals differentiate forms of anaphora depending on sentence structure, with selective impairment of sentences which involve construal with reference to context (anaphoric coreference). We argue that aMCI individuals maintain core structural knowledge while evidencing deficiency in syntax-semantics integration, thus locating the source of the deficit in the language-thought interface of the Language Faculty.

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来源期刊
Journal of Neurolinguistics
Journal of Neurolinguistics 医学-神经科学
CiteScore
3.90
自引率
5.00%
发文量
49
审稿时长
17.2 weeks
期刊介绍: The Journal of Neurolinguistics is an international forum for the integration of the neurosciences and language sciences. JNL provides for rapid publication of novel, peer-reviewed research into the interaction between language, communication and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in communication and its breakdowns. Contributions from neurology, communication disorders, linguistics, neuropsychology and cognitive science in general are welcome. Published articles will typically address issues relating some aspect of language or speech function to its neurological substrates with clear theoretical import. Interdisciplinary work on any aspect of the biological foundations of language and its disorders resulting from brain damage is encouraged. Studies of normal subjects, with clear reference to brain functions, are appropriate. Group-studies on well defined samples and case studies with well documented lesion or nervous system dysfunction are acceptable. The journal is open to empirical reports and review articles. Special issues on aspects of the relation between language and the structure and function of the nervous system are also welcome.
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