在均相催化条件下高效制备(+)-樟脑和(-)-葑酮苯胺的新方法

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Doklady Chemistry Pub Date : 2023-12-25 DOI:10.1134/S0012500823600700

A. A. Vernigora, R. V. Brunilin, V. V. Burmistrov, A. V. Davidenko, M. B. Nawrozkij, N. A. Salykin, V. V. Chernyshov, I. A. Novakov

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引用次数: 0

摘要

摘要开发了一种合成(+)-樟脑和(-)-葑酮苯胺的有效方法，包括在原位制备的(i-PrO)2Ti(OTf)2-(i-PrOH)2 复合物（作为均相催化剂）和(i-PrO)4Ti（作为脱水剂）存在下，使相应的双环单萜酮与取代苯胺反应。所建议方法的优点不仅在于可以获得收率高、纯度高的目标产物，还在于简化了分离过程。这些产品可作为潜在的药理活性化合物、橡胶混合物的抗氧化剂以及 3D 打印配方的成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

New Efficient Approach to the Preparation of (+)-Camphor and (–)-Fenchone Anils under Homogeneous Catalysis Conditions

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New Efficient Approach to the Preparation of (+)-Camphor and (–)-Fenchone Anils under Homogeneous Catalysis Conditions

An efficient approach to the synthesis of (+)-camphor and (–)-fenchone anils has been developed, which involves the reaction of the corresponding bicyclic monoterpenoid ketones with substituted anilines in the presence of in situ prepared (i-PrO)₂Ti(OTf)₂·(i-PrOH)₂ complex, as a homogeneous catalyst, and (i-PrO)₄Ti, as a dehydrating agent. The advantage of the suggested method lies not only in obtaining target products in good yield and high purity, but also in a simplified procedure for their isolation. These products are of interest as potential pharmacologically active compounds, antioxidants for rubber mixtures, and components of 3D-printing formulations.

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来源期刊

Doklady Chemistry 化学-化学综合

CiteScore

1.20

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.