利用基于机器学习算法的多尺度建模预测镁植入物的腐蚀情况

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Santu Mondal, Rahul Samanta, Sahadeb Shit, Arindam Biswas, Atul Bandyopadhyay, Rudra Sankar Dhar, Gurudas Mandal
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引用次数: 0

摘要

为了改善患者的治疗效果,减少与种植失败相关的社会和经济负担,持续的研究和开发至关重要。为此,在本研究中,已对镁植入物的腐蚀行为进行了预测。这包括植入材料、手术技术、感染预防策略以及考虑到每位患者独特特征的个性化医疗方法等方面的进步。最终,我们的目标是使骨科手术更安全、更有效。首要重点是尽量减少因腐蚀导致的植入失败等并发症,以提高患者的整体生活质量。骨科植入物周围的感染是植入物失效的主要原因。这些感染的治疗具有挑战性,因为植入物的存在会使人体免疫系统难以有效对抗感染。预防感染至关重要,通常需要在手术过程中进行严格的无菌操作。也可以预防性地使用抗生素。炎症是手术后的自然反应,但过度炎症会引起疼痛并导致并发症,包括植入失败。先进的材料和改良的手术技术可以降低无菌性松动的可能性。当种植体失效时,就必须进行翻修手术。种植体材料的选择是为了尽量减少腐蚀,但腐蚀仍然可能发生。腐蚀会导致种植体磨损和损坏,有可能引起炎症和种植体失效。外科医生和生产商不断寻求耐腐蚀性更好的材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Corrosion Prediction of Mg Implant using Multiscale Modelling based on Machine Learning Algorithms
To improve patient outcomes and reduce the social and financial burdens associated with implant failure, ongoing research and development are essential. For that in this study, MLA has been done to predict the corrosion behavior of Mg implant. This includes advancements in implant materials, surgical techniques, infection prevention strategies, and personalized medicine approaches that consider each patient's unique characteristics. Ultimately, the goal is to make orthopedic surgery safer and more effective. The primary focus is to minimize complications like implant failure due to corrosion to enhance the overall quality of life for patients. Infections around orthopedic implants are a major cause of implant failure. These infections can be challenging to treat because the implant’s presence can make it difficult for the body’s immune system to effectively combat the infection. Preventing infection is crucial and often involves strict sterile procedures during surgery. Antibiotics may also be prescribed prophylactically. Inflammation is a natural response to surgery, but excessive inflammation can cause pain and lead to complications, including implant failure. Advanced materials and improved surgical techniques are designed to reduce the likelihood of aseptic loosening. When an implant fails, revision surgery becomes necessary. Implant materials are chosen to minimize corrosion, but it can still occur. Corrosion can lead to wear and damage to the implant, potentially causing inflammation and implant failure. Surgeons and manufacturers continually seek materials with improved resistance to corrosion.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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