抑郁性肝炎患者的生物转化

Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1989-01-01

A Hoffmann, M Reinhardt, C Rechenbach, L Henschel, D Jorke

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引用次数: 0

摘要

本文对17例1年以上的二肼性肝炎患者进行了生物转化速度的研究，并与健康对照组进行了比较。17名患者中有15名，10名志愿者中有5名是慢乙酰化患者。所有慢速乙酰化剂都比快速乙酰化剂消除磺胺乙嘧啶的速度慢。——与对照组相比，二羟嗪诱发肝炎后，咖啡因和metamizol(氧化生物转化反应的测试物质)的消除延迟。慢速乙酰化药物必须小心控制，因为它们有较高的风险引起二羟嗪引起的药物性肝炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[Biotransformation in patients following Depressan-induced hepatitis].

In 17 patients who more than 1 year ago had suffered from a dihydralazine induced hepatitis the biotransformation velocity was investigated and compared with a healthy control group. 15 out of the 17 patients and 5 out of the 10 volunteers are slow acetylators. All slow acetylators eliminate sulfamethazine more slowly than rapid acetylators.--The elimination of caffeine and metamizol--test substances for oxidative biotransformation reactions--was retarded in patients after dihydralazine induced hepatitis in comparison to control persons. Slow acetylators have to be controlled carefully because of their higher risk of dihydralazine induced drug hepatitis.

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Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR

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