[线粒体相关内质网膜在与年龄有关的心血管疾病中的作用]。

Q3 Medicine
生理学报 Pub Date : 2023-12-25
Yu Zhang, Xin-Yi Zhao, Wen-Jun Xie, Yi Zhang
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引用次数: 0

摘要

线粒体相关内质网膜(MAMs)是线粒体和内质网(ER)之间的物理连接部位。作为控制ER和线粒体之间物质和信息交流的区室,MAMs参与调控各种病理生理过程,如钙平衡、线粒体形态和功能、脂质代谢和自噬。在过去的几十年中,越来越多的证据揭示了 MAMs 在多种心血管疾病(CVD)中的关键作用。衰老是心血管疾病的主要独立危险因素之一,它会引起心血管系统的逐渐退化,导致心血管疾病的发病率和死亡率增加。本综述旨在总结 MAMs 在与年龄相关的心血管疾病中的研究进展,并探索预防和治疗心血管疾病的新靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The role of mitochondria-associated endoplasmic reticulum membranes in age-related cardiovascular diseases].

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are the physical connection sites between mitochondria and endoplasmic reticulum (ER). As the compartments controlling substance and information communications between ER and mitochondria, MAMs were involved in the regulation of various pathophysiological processes, such as calcium homeostasis, mitochondrial morphology and function, lipid metabolism and autophagy. In the past decades, accumulating lines of evidence have revealed the pivotal role of MAMs in diverse cardiovascular diseases (CVD). Aging is one of the major independent risk factors for CVD, which causes progressive degeneration of the cardiovascular system, leading to increased morbidity and mortality of CVD. This review aims to summarize the research progress of MAMs in age-related CVD, and explore new targets for its prevention and treatment.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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