S90 小儿萎缩性变性胃炎:IPEX综合征的一种罕见表现形式

Alicia Olave-Pichon, Nishaben Patel
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引用次数: 0

摘要

所有患者均接受过至少6种其他IBD治疗失败。我们的研究结果显示,4名患者中有1名患者的症状有所改善,虽然不需要升级治疗,但内翻的影像学指标仍然不明确。此外,所有4名患者都因不良反应而需要停用西罗莫司。目前,关于西罗莫司治疗成人难治性IBD的数据极少,我们的研究结果表明,西罗莫司的作用可能会受到来自治疗的不良反应的限制。我们需要进一步开展大规模研究,探讨西罗莫司治疗难治性IBD的疗效,尤其要关注限制治疗的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
S90 Pediatric Atrophic Metaplastic Gastritis: A Rare Presentation of IPEX Syndrome
.Thiscaseseriespresented4patientswithCDwhoreceivedsirolimustherapyforaprimaryindicationofrefractoryCD.Allpatientshadfailedtreatmentwithatleast6otherIBD-therapies. Our results reveal 1 of 4 patients reporting symptomatic improvement and whilst treatment escalation was not required, imaging measures of in fl ammation remained equivocal. Furthermore, all 4 patients required sirolimus discontinuation due to adverse e ff ects. With minimal data currently available for use of sirolimus therapy in adults with refractory IBD, our fi ndings suggest that its role may be limited by treatment-derived adverse e ff ects. Further large-scale studies are needed to investigate the e ffi ciency of sirolimus therapy in refractory IBD, with particular attention to treatment-limiting adverse e ff ects.
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