模拟人体生理超级系统:肾脏和膀胱功能建模

R. Grygoryan, A. Degoda, T.V. Lyudovyk, O. Yurchak
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引用次数: 0

摘要

建立了一个描述人体肾脏和膀胱功能的定量模型。该模型作为一个自主的 C# 软件模块(SM)在给定的动态输入特征下运行,并进行了测试。最后,软件模块将被纳入我们的专用通用软件,该软件能够模拟人体综合生理学的主要模式,即生理超级系统(PSS)的相互作用。肾脏模型描述了血液在鲍曼囊中的过滤机制、集合管中的重吸收机制以及肾素-血管紧张素中央系统机制。膀胱模型描述了膀胱充盈和定期排空的动态过程。每次膀胱排空都是由大脑根据膀胱机械感受器的传入冲动模式产生的信号启动的。已使用设计情景的算法对模型进行了测试,包括模拟短时间或长时间(数小时或数天)的观察结果。输入数据包括肾脏传入动脉的压力、渗透压和肿瘤血压的不同组合。输出数据包括原尿、终尿、膀胱容量、尿压、机械感受器活动、肾素生成速度、血液中肾素浓度、血管紧张素 2 生成速度、血液中血管紧张素 2 浓度以及血液中白蛋白和钠浓度的动态变化。医学生和对理论研究感兴趣的生理学家都可以使用 SM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Simulating of human physiological supersystems: modeling of kidney and bladder functions
A quantitative model describing the functions of human kidney and bladder is created. The model is realized and tested as an autonomous C# software module (SM) functioning under given dynamic input characteristics. Finally, SM will be incorporated into our specialized general software capable of simulating the main modes of human integrative physiology, namely, interactions of physiological super-system (PSS). The model of the kidney describes mechanisms of blood filtration in Bowman’s capsule, reabsorption in collecting tubules, as well as the central renin-angiotensin system mechanism. The model of the bladder describes the dynamics of its filling and periodic emptying. Each act of bladder emptying is initiated by a signal generated by the brain in response to afferent impulse patterns from the bladder’s mechanoreceptors. Models have been tested using algorithms that design scenarios, including simulation of either short-time or long-time (hours or days) observations. Input data include different combinations of pressure in renal afferent arterioles, osmotic, and oncotic blood pressures. Output data includes dynamics of primary urine, final urine, bladder volume, urine pressure, mechanoreceptors’ activity, renin production velocity, blood renin concentration, angiotensin2 production velocity, and blood angiotensin2 concentration, as well as blood albumin and sodium concentrations. Both student-medics and physiologists interested in providing theoretical research can be users of SM.
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