{"title":"长非编码 RNA 在赫氏肺病中的研究进展","authors":"L Huang , M He , YM Liu , Z Jin","doi":"10.1016/j.yjpso.2023.100114","DOIUrl":null,"url":null,"abstract":"<div><p>Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNAs with transcript lengths >200 nucleotides. They play important roles in the regulation of gene expression through epigenetic mechanisms, such as chromatin remodeling, post-transcriptional processing, and acting as miRNA sponges. Recently, the involvement of lncRNAs in the pathogenesis of many diseases has been demonstrated. In this paper, we briefly review the latest progress in understanding the role of lncRNAs in the development of Hirschsprung disease (HSCR).</p></div>","PeriodicalId":100821,"journal":{"name":"Journal of Pediatric Surgery Open","volume":"5 ","pages":"Article 100114"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949711623001119/pdfft?md5=36b42b0b4e1be9bdc3c8ba97c675d8fa&pid=1-s2.0-S2949711623001119-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Advances in the study of long non-coding RNAs in Hirschsprung disease\",\"authors\":\"L Huang , M He , YM Liu , Z Jin\",\"doi\":\"10.1016/j.yjpso.2023.100114\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNAs with transcript lengths >200 nucleotides. They play important roles in the regulation of gene expression through epigenetic mechanisms, such as chromatin remodeling, post-transcriptional processing, and acting as miRNA sponges. Recently, the involvement of lncRNAs in the pathogenesis of many diseases has been demonstrated. In this paper, we briefly review the latest progress in understanding the role of lncRNAs in the development of Hirschsprung disease (HSCR).</p></div>\",\"PeriodicalId\":100821,\"journal\":{\"name\":\"Journal of Pediatric Surgery Open\",\"volume\":\"5 \",\"pages\":\"Article 100114\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2949711623001119/pdfft?md5=36b42b0b4e1be9bdc3c8ba97c675d8fa&pid=1-s2.0-S2949711623001119-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatric Surgery Open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949711623001119\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric Surgery Open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949711623001119","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Advances in the study of long non-coding RNAs in Hirschsprung disease
Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNAs with transcript lengths >200 nucleotides. They play important roles in the regulation of gene expression through epigenetic mechanisms, such as chromatin remodeling, post-transcriptional processing, and acting as miRNA sponges. Recently, the involvement of lncRNAs in the pathogenesis of many diseases has been demonstrated. In this paper, we briefly review the latest progress in understanding the role of lncRNAs in the development of Hirschsprung disease (HSCR).
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