研究用于治疗头痛疾病的经典迷幻剂:对退伍军人的考虑

IF 0.7 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
E. Schindler, Jason J. Sico
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引用次数: 0

摘要

概述 偏头痛或丛集性头痛等头痛疾病患者的生活质量往往很差,并可能因此致残。军人和退伍军人罹患头痛疾病的风险很高,尤其是因为他们还可能因头部外伤而导致脑损伤。我们需要新的头痛治疗方法,因为现有的治疗方法可能不起作用、副作用太大或负担不起。将迷幻药作为头痛症的一种治疗方法已经讨论了 50 多年。患者报告说,麦角酰二乙胺(一种合成迷幻剂)和迷幻药素(一种存在于所谓的神奇蘑菇中的化合物)等药物只需服用一次或几次,就能在数周或数月内持久缓解头痛。对这种独特能力的正式研究已经开始。关于迷幻蘑菇素治疗偏头痛和丛集性头痛的首批研究结果令人鼓舞,不过这些研究规模较小,还没有得出结论,还需要更多的研究。退伍军人在最近重新兴起的迷幻剂研究中表现活跃,尽管由于潜在的健康状况或从军经历中获得的观点,他们可能并不都能够或愿意参加研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Studying classic psychedelics for the management of headache disorders: Considerations for Veterans
LAY SUMMARY Patients with headache disorders, such as migraine or cluster headache, often have poor quality of life and can be disabled by their condition. Military members and Veterans have a high risk of developing a headache disorder, particularly because they are also at risk for brain injury through head trauma. New headache treatments are needed, because the available treatments may not work, have too many side effects, or are not affordable. Psychedelics have been discussed as a treatment in headache disorders for more than 50 years. Patients report that drugs such as lysergic acid diethylamide (a synthetic psychedelic) and psilocybin (a compound found in so-called magic mushrooms) provide long-lasting relief from headaches for weeks or months after just a single or few doses. Formal studies investigating this unique ability are starting to take place. Findings from the first studies of psilocybin in migraine and cluster headache are encouraging, although these studies are small and not conclusive, and more research is needed. Veterans have been active in the recent re-emergence of psychedelics, although they may not all be able, or willing, to take part in studies because of underlying health conditions or viewpoints gained through military experience.
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来源期刊
CiteScore
1.60
自引率
11.10%
发文量
72
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