新型三唑并吡啶衍生物及其抗癌活性

Q4 Earth and Planetary Sciences

Research Journal of Chemistry and Environment Pub Date : 2023-12-05 DOI:10.25303/281rjce21026

Swamy M. Kumara, K. Bhaskar

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引用次数: 0

摘要

从吡啶 1 开始，制备了一系列新型三唑官能化三氟甲基吡啶衍生物。化合物 1 与硫酸反应生成化合物 2，化合物 2 氯化后与水合肼反应生成化合物 3 和 4。化合物 4 与各种取代的脂肪族和芳香族酸氯化物反应后，生成了酰胺衍生物 4a-h 和 5a-h。评估了所有最终化合物对四种人类癌细胞系的抗癌活性，如 HeLa - 宫颈癌（CCL-2）；COLO 205 - 结肠癌（CCL-222）；HepG2 - 肝癌（HB-8065）；MCF7 - 乳腺癌（HTB-22）。发现了前景看好的化合物 4f 和 4g。

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Novel triazolo pyridine derivatives and their anti cancer activity

A series of novel triazole functionalized trifluoromethyl pyridine derivatives was prepared starting from pyridine 1. Compound 1 on reaction with sulphuric acid gave compound 2 which on chlorination followed by hydrazine hydrate and obtained compound 3 and 4. Compound 4 on reaction with diverse substituted aliphatic and aromatic acid chlorides produced amide derivatives 4a-h and 5a-h. All the final compounds were evaluated for anti cancer activity against four human cancer cell lines such as HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer (CCL-222); HepG2- Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22). Promising compounds 4f and 4g were identified.

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