关于洛神花(Hibiscus sabdariffa L.)抗高血压特性和毒性的综合体内研究

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Yasmiwar Susilawati, R. M. Febriyanti, E. Febrina, A. Chaerunisaa, S. Sumiwi
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引用次数: 0

摘要

背景:洛神花(Hibiscus sabdariffa L.)萼片在传统医学中被用作利尿剂、轻泻剂和降压药,但迄今为止,尚未对其药理活性和安全性进行全面研究。研究目的本研究旨在全面评估洛神花(H. sabdariffa L.)萼片提取物的抗高血压功效和毒性特征。研究利用动物模型评估了洛神花(H. sabdariffa L.)萼片提取物的剂量依赖性药理作用和安全性:研究结果表明,当剂量为 250 毫克/千克体重(BW)时,该提取物具有显著的降压效果,收缩压和舒张压分别降低了 10.12% 和 11.63%。醋酸乙酯馏分的剂量为 112.5 毫克/千克体重,其功效高于正己烷和水馏分,这表明活性化合物可能具有半极性。急性毒性测试结果表明,雄性大鼠的半数致死剂量为 8.75 克/千克体重,雌性大鼠的半数致死剂量为 7.5 克/千克体重,因此该提取物具有轻微毒性。亚慢性毒性研究表明,H. sabdariffa L. 对雄性和雌性大鼠的体重和尿素水平均有影响,但只有雌性大鼠的血液参数、肌酐水平和肝脏指数发生了变化。结论这些数据表明,H. sabdariffa L. 提取物具有治疗前景,但由于其潜在毒性,应谨慎给药,剂量最好低于 250 毫克/千克体重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comprehensive in vivo study of the antihypertensive properties and toxicity of roselle (Hibiscus sabdariffa L.)
Background: Roselle (Hibiscus sabdariffa L.) calyces have been used in traditional medicine as diuretics, mild laxatives, and antihypertensive agents but to date, a comprehensive study of its pharmacological activity and safety has not been conducted. Aims of the study: The current study aims to provide a comprehensive evaluation of the antihypertensive efficacy and toxicity profile of Roselle (H. sabdariffa L.) calyces extract. Utilizing animal models, the investigation assessed the dose-dependent pharmacological effects and safety of H. sabdariffa L. Results: The findings indicate that the extract exerts a significant antihypertensive effect at a dose of 250 mg/kg body weight (BW), lowering systolic and diastolic blood pressures by 10.12% and 11.63%, respectively. Ethyl acetate fractions administered at 112.5 mg/kg BW demonstrated greater efficacy than n-hexane and aqueous fractions, suggesting that the active compounds likely possess semi-polar properties. Acute toxicity testing yielded an LD50 of 8.75 g/kg BW for male rats and 7.5 g/kg BW for female rats, classifying the extract as slightly toxic. The sub-chronic toxicity study shows that H. sabdariffa L. demonstrates an effect on bodyweight and urea levels in male and female rats, while the change in the blood parameters, creatinine level, and the liver index was only observed in female rats. Conclusions: These data suggest that H. sabdariffa L. extract exhibits therapeutic promise but should be administered cautiously, preferably at doses lower than 250 mg/kg BW, due to potential toxicity.
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来源期刊
Pharmacia
Pharmacia PHARMACOLOGY & PHARMACY-
CiteScore
2.30
自引率
27.30%
发文量
114
审稿时长
12 weeks
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