吲哚基 1,2-丙二醇类生物碱，1-(1H-吲哚-3-氧基)丙-2-醇拟议结构的全合成

Q3 Chemistry

Chemistry Pub Date : 2023-12-12 DOI:10.3390/chemistry5040177

Momoko Kimata, Takumi Abe

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引用次数: 0

摘要

本论文首次描述了含有 1,2-丙二醇分子的史无前例的吲哚衍生物的全合成结构。通过吲哚鎓中间体对 3-烷氧基吲哚啉进行异构化是全合成的关键步骤。合成化合物的 1H、13C-NMR、IR 和 HRMS 光谱与最初报告的结构有很大不同，这表明天然产物需要修正。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Total Synthesis of the Proposed Structure of Indolyl 1,2-Propanediol Alkaloid, 1-(1H-Indol-3-yloxy)propan-2-ol

The first total synthesis of the proposed structure of unprecedented indolyl derivative bearing 1,2-propanediol moiety is described. Isomerization of 3-alkoxyindolines through indolenium intermediates was the key step in the total synthesis. 1H, 13C-NMR, IR, and HRMS spectra of the synthetic compound drastically differed to those of the originally reported structure, which suggests the natural product requires revision.

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来源期刊

Chemistry

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2017 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields.