Is Transdermal Delivery Potential Route for Sitagliptin Phosphate: The pH Control Effect

The objective of this study is to predict transdermal delivery as a potential route for sitagliptin phosphate. The partition coefficient of sitagliptin phosphate was measured in a chloroform-buffer system using the shake flask method at room temperature, and the analysis was performed under different pH conditions. Established mathematical equations were employed to calculate transdermal parameters. The results indicate that the logarithm partition coefficient values of the drug at pH 2.0 (0.354) and pH 3.0 (0.293) were higher compared to the control (0.274). Statistical analysis revealed the rejection of the null hypothesis at a 95% confidence level when comparing the mean partition coefficient of the drug at pH 2.0 to the mean partition coefficient of the drug in distilled water (control). In conclusion, the results suggest that using permeability coefficient as a reliable parameter, an aqueous solution of pH 2.0 would be the preferred vehicle to formulate a potential transdermal dosage form of sitagliptin phosphate.